TFAM transcription factor A, mitochondrial [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TFAMprovided by VGNC
Official Full Name: transcription factor A, mitochondrialprovided by VGNC
Primary source: VGNC:VGNC:35775
See related: Ensembl:ENSBTAG00000003546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	28	NC_037355.1 (45673449..45689736, complement)

Chromosome 28 - NC_037355.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.
Title: Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors.
Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.
Title: Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor A, mitochondrial

Names: mitochondrial transcription factor 1; mtTFA; transcription factor 6-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034016.2 → NP_001029188.2 transcription factor A, mitochondrial precursor

See identical proteins and their annotated locations for NP_001029188.2

Status: PROVISIONAL

Source sequence(s)

BC122754

UniProtKB/Swiss-Prot

Q0II87

Related

ENSBTAP00000052192.2, ENSBTAT00000052511.3

Conserved Domains (2) summary

cd01390
Location:155 → 216

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

pfam00505
Location:50 → 114

HMG_box; HMG (high mobility group) box