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    IRS4 insulin receptor substrate 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 492059, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IRS4provided by VGNC
    Official Full Name
    insulin receptor substrate 4provided by VGNC
    Primary source
    VGNC:VGNC:42100
    See related
    Ensembl:ENSCAFG00845020997
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (83925400..83942146, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (68396271..68412952, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (82887838..82904529, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (81384480..81401164, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (83096771..83113520, complement)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene collagen type IV alpha 5 chain Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene methylsterol monooxygenase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin receptor substrate 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      83925400..83942146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038450622.1 → XP_038306550.1  insulin receptor substrate 4

      UniProtKB/TrEMBL
      A0A8I3P6F6, A0A8I3PAR4
      Related
      ENSCAFP00845029005.1, ENSCAFT00845037042.1
      Conserved Domains (2) summary
      cd01204
      Location:231 → 334
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:77 → 202
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

    RNA

    1. XR_005309510.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      81384480..81401164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038524074.1 → XP_038380002.1  insulin receptor substrate 4

    RNA

    1. XR_005352294.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      83096771..83113520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038652566.1 → XP_038508494.1  insulin receptor substrate 4

    RNA

    1. XR_005420186.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      82887838..82904529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038588051.1 → XP_038443979.1  insulin receptor substrate 4

      UniProtKB/TrEMBL
      A0A8C0P2T2, A0A8C0YXA4

    RNA

    1. XR_005386400.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      68396271..68412952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005641658.3 → XP_005641715.2  insulin receptor substrate 4

      UniProtKB/TrEMBL
      A0A8P0PGX0, A0A8P0SMG3
      Conserved Domains (2) summary
      cd01204
      Location:231 → 334
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:77 → 202
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

    RNA

    1. XR_296936.3 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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