MC4R melanocortin 4 receptor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MC4Rprovided by VGNC
Official Full Name: melanocortin 4 receptorprovided by VGNC
Primary source: VGNC:VGNC:43067
See related: Ensembl:ENSCAFG00845000280
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (16003681..16004679)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (17102321..17103318)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (16214421..16215419)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (16032383..16033381)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (15964379..15965377)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results showed that the SNP at A420C was significantly associated with canine body weight trait when it changed amino acid 101 of the MC4R protein from asparagine to threonine
Title: SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs.
In a preliminary analysis of 187 Golden Retrievers, study found no association between the detected mc4r polymorphisms and morphological measures.
Title: Analysis of variation in the melanocortin-4 receptor gene (mc4r) in Golden Retriever dogs.
statistically significant relationship between MC4R polymorphism and body weight
Title: [Relationship between MC4R gene polymorphyism and body weight trait in beagle dogs].
Mapping of the MC4R gene by FISH to the canine chromosome 1 and to the red fox chromosome 5.
Title: Polymorphism and chromosomal location of the MC4R (melanocortin-4 receptor) gene in the dog and red fox.

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General gene information

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Markers

PMC314306P2 (e-PCR)
- UniSTS:272934

PMC314306P4 (e-PCR)
- UniSTS:272936

MC4R (e-PCR)
- UniSTS:266639

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables melanocyte-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: melanocortin receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.