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    PTPRM protein tyrosine phosphatase receptor type M [ Pan troglodytes (chimpanzee) ]

    Gene ID: 455298, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PTPRMprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Mprovided by VGNC
    Primary source
    VGNC:VGNC:9916
    Locus tag
    CK820_G0018410
    See related
    Ensembl:ENSPTRG00000009851
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (22499335..23325694, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (21420551..22246812, complement)

    Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene RAB12, member RAS oncogene family Neighboring gene E3 ubiquitin-protein ligase COP1-like Neighboring gene uncharacterized LOC107969438 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134808584 Neighboring gene uncharacterized LOC129137876 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase mu
    XP_009431930.2
    XP_009431931.2
    XP_009431933.2
    XP_009431935.2
    XP_009431938.2
    XP_054528023.1
    XP_054528024.1
    XP_054528025.1
    XP_054528028.1
    XP_054528029.1
    XP_054528030.1
    XP_063651597.1
    XP_063651598.1
    XP_512029.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      22499335..23325694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_512029.7 → XP_512029.4  receptor-type tyrosine-protein phosphatase mu isoform X8

      UniProtKB/TrEMBL
      A0A2J8MNV2, A0A8I3B129, K7B5N7, K7B779, K7CLF2
      Conserved Domains (7) summary
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:899 → 1153
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1215 → 1447
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:383 → 477
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain

    2. XM_009433655.5 → XP_009431930.2  receptor-type tyrosine-protein phosphatase mu isoform X1

      UniProtKB/TrEMBL
      A0A2J8MNY3
      Conserved Domains (6) summary
      smart00060
      Location:383 → 467
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd14633
      Location:918 → 1207
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1293 → 1498
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    3. XM_009433656.5 → XP_009431931.2  receptor-type tyrosine-protein phosphatase mu isoform X2

      UniProtKB/TrEMBL
      K7B5N7
      Conserved Domains (7) summary
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:383 → 477
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:909 → 1198
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1284 → 1489
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    4. XM_009433658.5 → XP_009431933.2  receptor-type tyrosine-protein phosphatase mu isoform X3

      UniProtKB/TrEMBL
      A0A2J8MNY3
      Conserved Domains (7) summary
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:383 → 477
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:918 → 1190
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1276 → 1481
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    5. XM_054672048.2 → XP_054528023.1  receptor-type tyrosine-protein phosphatase mu isoform X4

    6. XM_009433660.5 → XP_009431935.2  receptor-type tyrosine-protein phosphatase mu isoform X6

      UniProtKB/TrEMBL
      K7B5N7
      Conserved Domains (7) summary
      smart00060
      Location:282 → 361
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:899 → 1170
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1232 → 1464
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:383 → 477
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain

    7. XM_054672050.2 → XP_054528025.1  receptor-type tyrosine-protein phosphatase mu isoform X7

    8. XM_054672049.2 → XP_054528024.1  receptor-type tyrosine-protein phosphatase mu isoform X5

    9. XM_009433663.5 → XP_009431938.2  receptor-type tyrosine-protein phosphatase mu isoform X14

      UniProtKB/TrEMBL
      A0A2J8MNW3
      Conserved Domains (7) summary
      smart00060
      Location:69 → 148
      FN3; Fibronectin type 3 domain
      cd00063
      Location:170 → 264
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14633
      Location:671 → 943
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1029 → 1234
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:286 → 361
      fn3; Fibronectin type III domain
      pfam00047
      Location:19 → 61
      ig; Immunoglobulin domain
      pfam18861
      Location:443 → 550
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    10. XM_063795528.1 → XP_063651598.1  receptor-type tyrosine-protein phosphatase mu isoform X13

    11. XM_054672054.2 → XP_054528029.1  receptor-type tyrosine-protein phosphatase mu isoform X11

    12. XM_054672055.2 → XP_054528030.1  receptor-type tyrosine-protein phosphatase mu isoform X12

    13. XM_063795527.1 → XP_063651597.1  receptor-type tyrosine-protein phosphatase mu isoform X10

    14. XM_054672053.2 → XP_054528028.1  receptor-type tyrosine-protein phosphatase mu isoform X9

    Nucleotide Protein
    Heading Accession and Version

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