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    ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 452673, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ARHGEF7provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 7provided by VGNC
    Primary source
    VGNC:VGNC:13067
    Locus tag
    CK820_G0036387
    See related
    Ensembl:ENSPTRG00000006039
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 14 NC_072412.2 (116726552..116918139)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 13 NC_072411.1 (112066436..112258945)

    Chromosome 14 - NC_072412.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134808161 Neighboring gene uncharacterized LOC134808162 Neighboring gene uncharacterized LOC104001927 Neighboring gene uncharacterized LOC134808164 Neighboring gene testis expressed 29 Neighboring gene uncharacterized LOC134808165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 7
    Names
    Rho guanine nucleotide exchange factor (GEF) 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072412.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      116726552..116918139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054665565.2 → XP_054521540.1  rho guanine nucleotide exchange factor 7 isoform X4

    2. XM_016925546.4 → XP_016781035.1  rho guanine nucleotide exchange factor 7 isoform X8

      UniProtKB/TrEMBL
      A0A2I3RBZ3, A0A2I3SI90, A0A2J8KT88, A0A6D2W8M0
      Related
      ENSPTRP00000062187.1
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:773 → 859
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    3. XM_016925551.4 → XP_016781040.1  rho guanine nucleotide exchange factor 7 isoform X14

      UniProtKB/TrEMBL
      A0A2I3RNA6, A0A2J8KT97
      Related
      ENSPTRP00000066181.1
      Conserved Domains (7) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:613 → 711
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:714 → 800
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21266
      Location:3 → 115
      CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

    4. XM_063792336.1 → XP_063648406.1  rho guanine nucleotide exchange factor 7 isoform X17

    5. XM_054665566.2 → XP_054521541.1  rho guanine nucleotide exchange factor 7 isoform X5

    6. XM_016925549.4 → XP_016781038.1  rho guanine nucleotide exchange factor 7 isoform X10

      UniProtKB/TrEMBL
      A0A2I3TSY3, A0A2J8KT81, A0A6D2WU63

    7. XM_054665567.2 → XP_054521542.1  rho guanine nucleotide exchange factor 7 isoform X7

    8. XM_054665563.2 → XP_054521538.1  rho guanine nucleotide exchange factor 7 isoform X1

    9. XM_054665564.2 → XP_054521539.1  rho guanine nucleotide exchange factor 7 isoform X3

    10. XM_016925542.4 → XP_016781031.1  rho guanine nucleotide exchange factor 7 isoform X2

      UniProtKB/TrEMBL
      A0A2I3SI90, A0A2J8KT88, A0A6D2W8M0

    11. XM_016925544.4 → XP_016781033.1  rho guanine nucleotide exchange factor 7 isoform X6

      UniProtKB/TrEMBL
      A0A2I3SI90, A0A2J8KT88, A0A6D2W8M0

    12. XM_063792334.1 → XP_063648404.1  rho guanine nucleotide exchange factor 7 isoform X15

    13. XM_054665572.2 → XP_054521547.1  rho guanine nucleotide exchange factor 7 isoform X19

    14. XM_054665570.2 → XP_054521545.1  rho guanine nucleotide exchange factor 7 isoform X11

    15. XM_063792333.1 → XP_063648403.1  rho guanine nucleotide exchange factor 7 isoform X9

    16. XM_024348349.3 → XP_024204117.1  rho guanine nucleotide exchange factor 7 isoform X13

      UniProtKB/TrEMBL
      A0A2J8KT97
      Conserved Domains (8) summary
      cd12061
      Location:167 → 220
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00014
      Location:21 → 107
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:726 → 812
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:613 → 723
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:117 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl26464
      Location:564 → 647
      Atrophin-1; Atrophin-1 family

    17. XM_024348350.3 → XP_024204118.1  rho guanine nucleotide exchange factor 7 isoform X21

      UniProtKB/TrEMBL
      A0A2J8KT97
      Conserved Domains (6) summary
      cd12061
      Location:95 → 148
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:179 → 356
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:387 → 485
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:541 → 639
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:642 → 728
      betaPIX_CC; betaPIX coiled coil
      cl00030
      Location:3 → 89
      CH_SF; calponin homology (CH) domain superfamily

    18. XM_063792341.1 → XP_063648411.1  rho guanine nucleotide exchange factor 7 isoform X24

    19. XM_063792349.1 → XP_063648419.1  rho guanine nucleotide exchange factor 7 isoform X27

    20. XM_063792344.1 → XP_063648414.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83

    21. XM_054665575.2 → XP_054521550.1  rho guanine nucleotide exchange factor 7 isoform X26

      UniProtKB/TrEMBL
      A0A2J8KT69

    22. XM_024348355.3 → XP_024204123.1  rho guanine nucleotide exchange factor 7 isoform X26

      UniProtKB/TrEMBL
      A0A2J8KT69
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:557 → 643
      betaPIX_CC; betaPIX coiled coil

    23. XM_054665571.2 → XP_054521546.1  rho guanine nucleotide exchange factor 7 isoform X18

    24. XM_016925554.4 → XP_016781043.1  rho guanine nucleotide exchange factor 7 isoform X18

      UniProtKB/TrEMBL
      H2Q7T3
      Conserved Domains (6) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 430
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:320 → 430
      PH; PH domain
      pfam16523
      Location:658 → 744
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:486 → 596
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    25. XM_063792339.1 → XP_063648409.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83

    26. XM_054665574.2 → XP_054521549.1  rho guanine nucleotide exchange factor 7 isoform X26

      UniProtKB/TrEMBL
      A0A2J8KT69

    27. XM_024348352.3 → XP_024204120.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83, H2Q7T3
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:616 → 702
      betaPIX_CC; betaPIX coiled coil

    28. XM_063792351.1 → XP_063648421.1  rho guanine nucleotide exchange factor 7 isoform X26

      UniProtKB/TrEMBL
      A0A2J8KT69

    29. XM_054665573.2 → XP_054521548.1  rho guanine nucleotide exchange factor 7 isoform X24

    30. XM_024348354.3 → XP_024204122.1  rho guanine nucleotide exchange factor 7 isoform X27

      Conserved Domains (6) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:569 → 655
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:456 → 566
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:407 → 490
      Atrophin-1; Atrophin-1 family

    31. XM_063792353.1 → XP_063648423.1  rho guanine nucleotide exchange factor 7 isoform X28

    32. XM_063792354.1 → XP_063648424.1  rho guanine nucleotide exchange factor 7 isoform X29

    33. XM_063792342.1 → XP_063648412.1  rho guanine nucleotide exchange factor 7 isoform X24

    34. XM_063792350.1 → XP_063648420.1  rho guanine nucleotide exchange factor 7 isoform X27

    35. XM_063792345.1 → XP_063648415.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83

    36. XM_063792348.1 → XP_063648418.1  rho guanine nucleotide exchange factor 7 isoform X25

    37. XM_063792338.1 → XP_063648408.1  rho guanine nucleotide exchange factor 7 isoform X18

    38. XM_063792343.1 → XP_063648413.1  rho guanine nucleotide exchange factor 7 isoform X24

    39. XM_063792347.1 → XP_063648417.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83

    40. XM_009427254.5 → XP_009425529.1  rho guanine nucleotide exchange factor 7 isoform X26

      See identical proteins and their annotated locations for XP_009425529.1

      UniProtKB/TrEMBL
      A0A2J8KT69
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:557 → 643
      betaPIX_CC; betaPIX coiled coil

    41. XM_016925558.4 → XP_016781047.1  rho guanine nucleotide exchange factor 7 isoform X18

      UniProtKB/TrEMBL
      H2Q7T3
      Conserved Domains (6) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 430
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:320 → 430
      PH; PH domain
      pfam16523
      Location:658 → 744
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:486 → 596
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    42. XM_024348353.3 → XP_024204121.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83, H2Q7T3
      Conserved Domains (5) summary
      cd12061
      Location:10 → 63
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:94 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:302 → 400
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:456 → 554
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:616 → 702
      betaPIX_CC; betaPIX coiled coil

    43. XM_063792337.1 → XP_063648407.1  rho guanine nucleotide exchange factor 7 isoform X18

    44. XM_063792340.1 → XP_063648410.1  rho guanine nucleotide exchange factor 7 isoform X24

    45. XM_009427240.5 → XP_009425515.1  rho guanine nucleotide exchange factor 7 isoform X12

      UniProtKB/TrEMBL
      H2Q7T3
      Conserved Domains (7) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 505
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:395 → 505
      PH; PH domain
      pfam16523
      Location:733 → 819
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:561 → 671
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:35 → 81
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    46. XM_063792335.1 → XP_063648405.1  rho guanine nucleotide exchange factor 7 isoform X16

    47. XM_003314212.7 → XP_003314260.1  rho guanine nucleotide exchange factor 7 isoform X22

      See identical proteins and their annotated locations for XP_003314260.1

      UniProtKB/TrEMBL
      A0A2J8KT97
      Conserved Domains (7) summary
      cd12061
      Location:85 → 138
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:169 → 346
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:377 → 475
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:395 → 475
      PH; PH domain
      pfam16523
      Location:632 → 718
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:531 → 629
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:35 → 81
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    48. XM_063792346.1 → XP_063648416.1  rho guanine nucleotide exchange factor 7 isoform X23

      UniProtKB/TrEMBL
      A0A2J8KT83

    49. XM_063792352.1 → XP_063648422.1  rho guanine nucleotide exchange factor 7 isoform X26

      UniProtKB/TrEMBL
      A0A2J8KT69

    50. XM_016925545.4 → XP_016781034.2  rho guanine nucleotide exchange factor 7 isoform X20

      Conserved Domains (6) summary
      cd12061
      Location:140 → 193
      SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
      cd00160
      Location:224 → 401
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:432 → 560
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:788 → 874
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:616 → 726
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      cl26464
      Location:565 → 646
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein
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