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    INS insulin [ Pan troglodytes (chimpanzee) ]

    Gene ID: 449570, updated on 29-Mar-2024

    Summary

    Official Symbol
    INSprovided by VGNC
    Official Full Name
    insulinprovided by VGNC
    Primary source
    VGNC:VGNC:1070
    See related
    Ensembl:ENSPTRG00000003172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
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    Genomic context

    Location:
    chromosome: 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (6426975..6428747, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) Unplaced Scaffold NW_026545376.1 (114368..116140, complement)

    Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134807287 Neighboring gene uncharacterized LOC134807324 Neighboring gene insulin like growth factor 2 Neighboring gene IGF2 antisense RNA Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    insulin
    Names
    preproinsulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008996.2NP_001008996.1  insulin preproprotein

      See identical proteins and their annotated locations for NP_001008996.1

      Status: VALIDATED

      Source sequence(s)
      X61089
      UniProtKB/Swiss-Prot
      P30410
      Related
      ENSPTRP00000005606.4, ENSPTRT00000006075.5
      Conserved Domains (1) summary
      cd04367
      Location:26110
      IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      6426975..6428747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016919751.3XP_016775240.2  insulin isoform X1