MSMB microseminoprotein beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: MSMBprovided by HGNC
Official Full Name: microseminoprotein betaprovided by HGNC
Primary source: HGNC:HGNC:7372
See related: Ensembl:ENSG00000263639 MIM:157145; AllianceGenome:HGNC:7372
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
Summary: The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward prostate (RPKM 2642.5) See more
Orthologs: mouse all
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Genomic context

Location:: 10q11.22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (46033313..46046269, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (46914187..46927144, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (51549553..51562509)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
Title: Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
Title: A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
Low plasma microseminoprotein-beta levels are associated with prostate cancer.
Title: The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition.
Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients.
Title: Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
Studies indicate prostate secretory protein of 94 amino acids (PSP94) as a prostate tumor marker [Review].
Title: Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.
this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
Title: MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
PSP94 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
Title: Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.
Results identified CRISP2 as a potential binding protein of PSP94 from human sperm.
Title: Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk
Title: Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.
Based on nasopharyngeal MSP gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
Title: Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Prostate cancer, hereditary, 13 MedGen: C2677821 OMIM: 611928 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genetic correction of PSA values using sequence variants associated with PSA levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan for variants associated with early-onset prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies genetic determinants of urine PCA3 levels in men. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies new prostate cancer susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci identified in a genome-wide association study of prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple newly identified loci associated with prostate cancer susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC35292 (e-PCR)
- UniSTS:61048

STS-X57928 (e-PCR)
- UniSTS:36288

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: beta-microseminoprotein

Names: immunoglobulin binding factor; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids; seminal plasma beta-inhibin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011551.1 RefSeqGene

Range

5001..17957

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002443.4 → NP_002434.1 beta-microseminoprotein isoform a precursor

See identical proteins and their annotated locations for NP_002434.1

Status: REVIEWED

Description

Transcript Variant: This variant (PSP94) encodes the full length isoform (a).

Source sequence(s)

BC005257, BM856408

Consensus CDS

CCDS73096.1

UniProtKB/Swiss-Prot

B1API6, P08118, P11999, Q13125, Q6IAY9, Q9UC59

UniProtKB/TrEMBL

B2R597

Related

ENSP00000463092.1, ENST00000582163.3

Conserved Domains (1) summary

pfam05825
Location:21 → 114

PSP94; Beta-microseminoprotein (PSP-94)
NM_138634.3 → NP_619540.1 beta-microseminoprotein isoform b precursor

See identical proteins and their annotated locations for NP_619540.1

Status: REVIEWED

Description

Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

BF680662

Consensus CDS

CCDS73095.1

UniProtKB/Swiss-Prot

P08118

Related

ENSP00000462641.1, ENST00000581478.5