ophn1 oligophrenin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ophn1provided by ZNC
Official Full Name: oligophrenin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-464
See related: Ensembl:ENSDARG00000035420 AllianceGenome:ZFIN:ZDB-GENE-040718-464
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92603
Summary: Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Human ortholog(s) of this gene implicated in X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance. Orthologous to human OPHN1 (oligophrenin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (35682675..35743741, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (35082522..35143588, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fi71b02.x1 (e-PCR)
- UniSTS:197891

G45756 (e-PCR)
- UniSTS:106558

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oligophrenin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

35682675..35743741 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002709.1 → NP_001002709.1

UniProtKB/TrEMBL

Q6DH84

Conserved Domains (1) summary

cl12013
Location:19 → 217

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394592.1 Reference GRCz11 ALT_DRER_TU_1

Range

151274..207151 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002709.1 → NP_001002709.1

UniProtKB/TrEMBL

Q6DH84

Conserved Domains (1) summary

cl12013
Location:19 → 217

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001002709.1: Suppressed sequence

Description

NM_001002709.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: OPHN1 (GeneID:4983).