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    UGDH UDP-glucose 6-dehydrogenase [ Gallus gallus (chicken) ]

    Gene ID: 422792, updated on 3-Apr-2024

    Summary

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    Symbol
    UGDHprovided by CGNC
    Full Name
    UDP-glucose 6-dehydrogenaseprovided by CGNC
    Primary source
    CGNC:51825
    See related
    Ensembl:ENSGALG00010016382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    UDPGDH; UDP-GlcDH
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (68772849..68794039)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (68758388..68779576)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532326 Neighboring gene ubiquitin conjugating enzyme E2 K Neighboring gene small integral membrane protein 14 Neighboring gene lipoic acid synthetase Neighboring gene ribosomal protein L9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis. Clarkin CE, et al. J Cell Physiol, 2011 Mar. PMID 20717929
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate a more diverse role for UGDH in the support of selective Glycosaminoglycans production than previously described.
      Title: Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosaminoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucose 6-dehydrogenase
    Names
    UDP-Glc dehydrogenase
    UDP-glucose dehydrogenase
    NP_001012599.1
    NP_001383937.1
    NP_001383938.1
    XP_025005461.1
    XP_046772217.1
    XP_046772218.1
    XP_046796142.1
    XP_046796143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012581.2 → NP_001012599.1  UDP-glucose 6-dehydrogenase isoform 2

      See identical proteins and their annotated locations for NP_001012599.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      Q5F3T9
      UniProtKB/TrEMBL
      A0A8V0Z2B6
      Related
      ENSGALP00010022768.1, ENSGALT00010039459.1
      Conserved Domains (1) summary
      PLN02353
      Location:4 → 464
      PLN02353; probable UDP-glucose 6-dehydrogenase

    2. NM_001397008.1 → NP_001383937.1  UDP-glucose 6-dehydrogenase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0Z2B6, A0A8V0Z2D4
      Conserved Domains (1) summary
      PLN02353
      Location:9 → 469
      PLN02353; probable UDP-glucose 6-dehydrogenase

    3. NM_001397009.1 → NP_001383938.1  UDP-glucose 6-dehydrogenase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/TrEMBL
      A0A8V0Z2B6
      Conserved Domains (1) summary
      PLN02353
      Location:4 → 462
      PLN02353; probable UDP-glucose 6-dehydrogenase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      68772849..68794039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025149693.3 → XP_025005461.1  UDP-glucose 6-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z2B6, A0A8V0Z2D4
      Related
      ENSGALP00010022776.1, ENSGALT00010039472.1
      Conserved Domains (1) summary
      PLN02353
      Location:9 → 469
      PLN02353; probable UDP-glucose 6-dehydrogenase

    2. XM_046940187.1 → XP_046796143.1  UDP-glucose 6-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z2D4

    3. XM_046940186.1 → XP_046796142.1  UDP-glucose 6-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z2D4
      Related
      ENSGALP00010022761.1, ENSGALT00010039449.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      68758388..68779576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046916261.1 → XP_046772217.1  UDP-glucose 6-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z2D4

    2. XM_046916262.1 → XP_046772218.1  UDP-glucose 6-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z2D4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F3T9.1 GenPept UniProtKB/Swiss-Prot:Q5F3T9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.