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    TWF2 twinfilin actin binding protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 415940, updated on 3-Apr-2024

    Summary

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    Symbol
    TWF2provided by CGNC
    Full Name
    twinfilin actin binding protein 2provided by CGNC
    Primary source
    CGNC:50121
    See related
    Ensembl:ENSGALG00010027440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PTK9L
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (3129710..3148083, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (3179255..3197652, complement)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene maestro heat-like repeat-containing protein family member 7 Neighboring gene HEAT repeat-containing protein 8 like 3 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene microRNA let-7g Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene WD repeat domain 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twinfilin-2
    Names
    PTK9L protein tyrosine kinase 9-like (A6-related protein)
    twinfilin, actin-binding protein, homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030589.2 → NP_001025760.2  twinfilin-2

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000252
      UniProtKB/Swiss-Prot
      Q5ZM35
      Related
      ENSGALP00010040740.1, ENSGALT00010066512.1
      Conserved Domains (2) summary
      cd11284
      Location:176 → 311
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      3129710..3148083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040646193.2 → XP_040502127.1  twinfilin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8V1AGP1
      Related
      ENSGALP00010040745.1, ENSGALT00010066520.1
      Conserved Domains (2) summary
      cd11284
      Location:239 → 374
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    2. XM_040646195.2 → XP_040502129.1  twinfilin-2 isoform X7

      UniProtKB/TrEMBL
      A0A8V1A992
      Related
      ENSGALP00010040741.1, ENSGALT00010066513.1
      Conserved Domains (2) summary
      cd11284
      Location:223 → 358
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    3. XM_015292836.3 → XP_015148322.2  twinfilin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8V1A992
      Conserved Domains (2) summary
      cd11284
      Location:228 → 363
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    4. XM_015292835.3 → XP_015148321.2  twinfilin-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V1A992
      Conserved Domains (2) summary
      cd11284
      Location:239 → 374
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    5. XM_015292834.3 → XP_015148320.2  twinfilin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A992
      Conserved Domains (2) summary
      cd11284
      Location:250 → 385
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    6. XM_015292830.3 → XP_015148316.2  twinfilin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A992
      Conserved Domains (2) summary
      cd11284
      Location:286 → 421
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    7. XM_040646192.2 → XP_040502126.1  twinfilin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AGP1
      Conserved Domains (2) summary
      cd11284
      Location:270 → 405
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:39 → 173
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    8. XM_040646196.2 → XP_040502130.1  twinfilin-2 isoform X8

      Conserved Domains (1) summary
      cd11285
      Location:53 → 189
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3179255..3197652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926235.1 → XP_046782191.1  twinfilin-2 isoform X4

    2. XM_046926238.1 → XP_046782194.1  twinfilin-2 isoform X7

    3. XM_046926237.1 → XP_046782193.1  twinfilin-2 isoform X6

    4. XM_046926236.1 → XP_046782192.1  twinfilin-2 isoform X5

    5. XM_046926234.1 → XP_046782190.1  twinfilin-2 isoform X3

    6. XM_046926232.1 → XP_046782188.1  twinfilin-2 isoform X1

    7. XM_046926233.1 → XP_046782189.1  twinfilin-2 isoform X2

    8. XM_046926239.1 → XP_046782195.1  twinfilin-2 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZM35.1 GenPept UniProtKB/Swiss-Prot:Q5ZM35

    Gene LinkOut

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