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    ALOX12 arachidonate 12-lipoxygenase, 12S type [ Bos taurus (cattle) ]

    Gene ID: 407169, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ALOX12provided by VGNC
    Official Full Name
    arachidonate 12-lipoxygenase, 12S typeprovided by VGNC
    Primary source
    VGNC:VGNC:25841
    See related
    BGD:BT10598; Ensembl:ENSBTAG00000021933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    12-LOX
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (26787205..26800876)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442630 Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene CUE domain-containing protein 2-like Neighboring gene uncharacterized LOC107131510 Neighboring gene chromosome 19 C17orf49 homolog Neighboring gene ribonuclease K

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The scurs locus in cattle maps to bovine chromosome 19. Asai M, et al. Anim Genet, 2004 Feb. PMID 14731227
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables arachidonate 15-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables linoleate 13S-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyunsaturated fatty acid lipoxygenase ALOX12
    NP_001179265.1
    XP_005220252.1
    XP_010814200.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192336.1 → NP_001179265.1  polyunsaturated fatty acid lipoxygenase ALOX12

      See identical proteins and their annotated locations for NP_001179265.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000019
      UniProtKB/TrEMBL
      F1MFA8, Q95103
      Related
      ENSBTAP00000029240.5, ENSBTAT00000029240.7
      Conserved Domains (2) summary
      cd01753
      Location:2 → 111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      cl27717
      Location:221 → 654
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26787205..26800876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010815898.4 → XP_010814200.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1

      UniProtKB/TrEMBL
      Q95103
      Related
      ENSBTAP00000090492.1, ENSBTAT00000125725.1
      Conserved Domains (2) summary
      cd01753
      Location:2 → 111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      cl27717
      Location:221 → 597
      Lipoxygenase; Lipoxygenase

    2. XM_005220195.5 → XP_005220252.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X2

      UniProtKB/TrEMBL
      Q95103
      Related
      ENSBTAP00000085696.1, ENSBTAT00000128624.1
      Conserved Domains (2) summary
      cd01753
      Location:2 → 111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:221 → 547
      Lipoxygenase; Lipoxygenase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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