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    fibpb fibroblast growth factor (acidic) intracellular binding protein b [ Danio rerio (zebrafish) ]

    Gene ID: 405787, updated on 27-Mar-2024

    Summary

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    Official Symbol
    fibpbprovided by ZNC
    Official Full Name
    fibroblast growth factor (acidic) intracellular binding protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040630-2
    See related
    Ensembl:ENSDARG00000020811 Ensembl:ENSDARG00000087666 AllianceGenome:ZFIN:ZDB-GENE-040630-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fibpl; zgc:103503
    Summary
    Predicted to enable fibroblast growth factor binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; cilium assembly; and convergent extension. Located in nucleus. Is expressed in forerunner cell group. Orthologous to human FIBP (FGF1 intracellular binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (25589121..25613249, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (25568763..25576644, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene neuronal PAS domain protein 4b Neighboring gene EGF containing fibulin extracellular matrix protein 2b Neighboring gene FOS like 1, AP-1 transcription factor subunit b Neighboring gene transmembrane protein 223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Hong SK, et al. Proc Natl Acad Sci U S A, 2009 Feb 17. PMID 19164561, Free PMC Article
    2. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. Kubra K, et al. Int J Mol Sci, 2022 Sep 3. PMID 36077499, Free PMC Article
    3. Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. Kuretani A, et al. BMC Ecol Evol, 2021 Jul 29. PMID 34325655, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC103503

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acidic fibroblast growth factor intracellular-binding protein B
    Names
    FGF-1 intracellular-binding protein B
    aFGF intracellular binding protein
    aFGF intracellular-binding protein B
    fibroblast growth factor (acidic) intracellular binding protein, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212861.2 → NP_998026.1  acidic fibroblast growth factor intracellular-binding protein B

      See identical proteins and their annotated locations for NP_998026.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085535
      UniProtKB/Swiss-Prot
      Q6T938
      Related
      ENSDARP00000119615.1, ENSDART00000137896.3
      Conserved Domains (1) summary
      pfam05427
      Location:1 → 354
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      25589121..25613249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468796.1 → XP_021324471.1  acidic fibroblast growth factor intracellular-binding protein B isoform X1

      UniProtKB/TrEMBL
      B0JZM9, Q5WQV6, Q5WQV7
      Conserved Domains (3) summary
      smart00179
      Location:120 → 153
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:180 → 203
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:195 → 235
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_021468795.1 → XP_021324470.1  acidic fibroblast growth factor intracellular-binding protein B isoform X1

      UniProtKB/TrEMBL
      B0JZM9, Q5WQV6, Q5WQV7
      Related
      ENSDARP00000116946.1, ENSDART00000139460.3
      Conserved Domains (3) summary
      smart00179
      Location:120 → 153
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:180 → 203
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:195 → 235
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_021468794.1 → XP_021324469.1  acidic fibroblast growth factor intracellular-binding protein B isoform X1

      UniProtKB/TrEMBL
      B0JZM9, Q5WQV6, Q5WQV7
      Conserved Domains (3) summary
      smart00179
      Location:120 → 153
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:180 → 203
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:195 → 235
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_021468797.1 → XP_021324472.1  acidic fibroblast growth factor intracellular-binding protein B isoform X3

      UniProtKB/TrEMBL
      A0A8M9P390
      Conserved Domains (1) summary
      pfam05427
      Location:1 → 339
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    5. XM_021468798.1 → XP_021324473.1  acidic fibroblast growth factor intracellular-binding protein B isoform X4

      UniProtKB/TrEMBL
      A0A8M9PCK3
      Conserved Domains (1) summary
      pfam05427
      Location:1 → 333
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    6. XM_009295296.3 → XP_009293571.1  acidic fibroblast growth factor intracellular-binding protein B isoform X2

      See identical proteins and their annotated locations for XP_009293571.1

      UniProtKB/TrEMBL
      A0A8M3AM40, F1Q5H6, F6NJ31
      Conserved Domains (1) summary
      pfam05427
      Location:1 → 354
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    7. XM_009295297.3 → XP_009293572.1  acidic fibroblast growth factor intracellular-binding protein B isoform X2

      See identical proteins and their annotated locations for XP_009293572.1

      UniProtKB/TrEMBL
      A0A8M3AM40, F1Q5H6, F6NJ31
      Conserved Domains (1) summary
      pfam05427
      Location:1 → 354
      FIBP; Acidic fibroblast growth factor binding (FIBP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T938.1 GenPept UniProtKB/Swiss-Prot:Q6T938

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