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    SPCS3 signal peptidase complex subunit 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 404005, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SPCS3provided by VGNC
    Official Full Name
    signal peptidase complex subunit 3provided by VGNC
    Primary source
    VGNC:VGNC:82299
    See related
    Ensembl:ENSCAFG00845018970
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    SPC22; SPC22/23
    Orthologs
    human mouse all
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    Genomic context

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    See SPCS3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (55569334..55582729, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (48756658..48769237, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (54297870..54310703, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (53463220..53476366, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (54059627..54072563, complement)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090358 Neighboring gene uncharacterized LOC106559854 Neighboring gene uncharacterized LOC102152375 Neighboring gene ankyrin repeat and SOCS box containing 5 Neighboring gene spermatogenesis associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex. Shelness GS, et al. J Biol Chem, 1988 Nov 15. PMID 3053702
    2. Membrane topology and biogenesis of eukaryotic signal peptidase. Shelness GS, et al. J Biol Chem, 1993 Mar 5. PMID 8444896
    3. Purification of microsomal signal peptidase as a complex. Evans EA, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3511473, Free PMC Article
    4. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies KU, et al. J Biol Chem, 1996 Feb 16. PMID 8632014

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in protein targeting to ER IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal peptidase complex subunit 3
    Names
    SPase 22 kDa subunit
    SPase 22/23 kDa subunit
    microsomal signal peptidase 22/23 kDa subunit
    microsomal signal peptidase 23 kDa subunit
    signal peptidase complex subunit 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      55569334..55582729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038690316.1 → XP_038546244.1  signal peptidase complex subunit 3

      UniProtKB/Swiss-Prot
      P61008
      UniProtKB/TrEMBL
      A0A8C0LH13, A0A8C0MT82
      Related
      ENSCAFP00845026279.1, ENSCAFT00845033569.1
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      53463220..53476366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038498011.1 → XP_038353939.1  signal peptidase complex subunit 3

      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      54059627..54072563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038624538.1 → XP_038480466.1  signal peptidase complex subunit 3

      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      54297870..54310703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038560497.1 → XP_038416425.1  signal peptidase complex subunit 3

      UniProtKB/Swiss-Prot
      P61008
      UniProtKB/TrEMBL
      A0A8C0LH13, A0A8C0MT82
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      48756658..48769237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038452568.1 → XP_038308496.1  signal peptidase complex subunit 3

      UniProtKB/Swiss-Prot
      P61008
      UniProtKB/TrEMBL
      A0A8C0LH13, A0A8C0MT82
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003314.1: Suppressed sequence

      Description
      NM_001003314.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61008.1 GenPept UniProtKB/Swiss-Prot:P61008

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