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    SAG S-antigen visual arrestin [ Canis lupus familiaris (dog) ]

    Gene ID: 403906, updated on 4-Apr-2024

    Summary

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    Official Symbol
    SAGprovided by VGNC
    Official Full Name
    S-antigen visual arrestinprovided by VGNC
    Primary source
    VGNC:VGNC:45846
    See related
    Ensembl:ENSCAFG00845021999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    ARR; sag1
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (45060350..45103430)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (45307685..45338815)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (44997874..45029086)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (44996643..45027722)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (44842616..44873724)

    Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 1 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene diacylglycerol kinase delta Neighboring gene ubiquitin specific peptidase 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs. Goldstein O, et al. Mol Vis, 2013. PMID 24019744, Free PMC Article
    2. Screening of the arrestin gene in dogs afflicted with generalized progressive retinal atrophy. Dekomien G, et al. BMC Genet, 2002 Jul 17. PMID 12123530, Free PMC Article
    3. Isolation of canine retinal arrestin cDNA and exclusion of three candidate genes for Swedish Briard retinal dystrophy. Veske A, et al. Curr Eye Res, 1997 Mar. PMID 9088745

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-stop SAG mutation in dogs affected with retinal degeneration was identified.
      Title: A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-arrestin
    Names
    48 kDa protein
    S-AG
    S-antigen; retina and pineal gland (arrestin)
    arrestin, S-antigen
    retinal S-antigen
    rod photoreceptor arrestin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003230.1 → NP_001003230.1  S-arrestin

      See identical proteins and their annotated locations for NP_001003230.1

      Status: PROVISIONAL

      Source sequence(s)
      X98460
      UniProtKB/Swiss-Prot
      Q28281
      UniProtKB/TrEMBL
      A0A8C0P8Z0, A0A8P0TG75
      Related
      ENSCAFP00845030408.1, ENSCAFT00845038830.1
      Conserved Domains (2) summary
      smart01017
      Location:203 → 364
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:26 → 184
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051829.1 Reference ROS_Cfam_1.0

      Range
      45060350..45103430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038434537.1 → XP_038290465.1  S-arrestin isoform X1

      UniProtKB/TrEMBL
      A0A8C0P8Z0, A0A8C0PHG6, A0A8I3P9Q1, A0A8P0TG75
      Conserved Domains (2) summary
      smart01017
      Location:203 → 364
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:26 → 184
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. XM_038434536.1 → XP_038290464.1  S-arrestin isoform X1

      UniProtKB/TrEMBL
      A0A8C0P8Z0, A0A8C0PHG6, A0A8I3P9Q1, A0A8P0TG75
      Conserved Domains (2) summary
      smart01017
      Location:203 → 364
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:26 → 184
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. XM_038434538.1 → XP_038290466.1  S-arrestin isoform X2

      UniProtKB/TrEMBL
      A0A8I3PAE9, A0A8I3PIN4
      Related
      ENSCAFP00845030491.1, ENSCAFT00845038936.1
      Conserved Domains (2) summary
      smart01017
      Location:203 → 364
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:26 → 184
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049285.1 Alternate UMICH_Zoey_3.1

      Range
      44996643..45027722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

      Range
      44842616..44873724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

      Range
      44997874..45029086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      45307685..45338815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28281.1 GenPept UniProtKB/Swiss-Prot:Q28281

    Gene LinkOut

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