U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GHRL ghrelin and obestatin prepropeptide [ Canis lupus familiaris (dog) ]

    Gene ID: 403587, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GHRLprovided by VGNC
    Official Full Name
    ghrelin and obestatin prepropeptideprovided by VGNC
    Primary source
    VGNC:VGNC:41209
    See related
    Ensembl:ENSCAFG00845007901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    MTLRP; MTLRP-AP
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GHRL in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (8122116..8127217)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (8127316..8131869)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (8163907..8168460)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (7844540..7849093)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (8190266..8194819)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene ATPase plasma membrane Ca2+ transporting 2 Neighboring gene uncharacterized LOC111091240 Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene TatD DNase domain containing 2 Neighboring gene interleukin 1 receptor associated kinase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart. Mitacchione G, et al. Circ Heart Fail, 2014 Jul. PMID 24855152, Free PMC Article
    2. A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration. Majchrzak K, et al. BMC Vet Res, 2012 Sep 23. PMID 22999388, Free PMC Article
    3. Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus. Tomasetto C, et al. Peptides, 2001 Dec. PMID 11786190
    4. Coronary vasoconstrictor effect of ghrelin is not mediated by growth hormone secretagogue receptor 1a type in dogs. Sax B, et al. Peptides, 2011 Feb. PMID 21126551

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ghrelin is an endogenously produced peptide; hence, it might prove a biocompatible candidate for the correction of cardiac metabolic alterations.
      Title: The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart.
    2. These experiments conducted in vitro confirmed that ghrelin promotes cancer development and metastasis.
      Title: A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration.
    3. Ghrelin induces tone-dependent constriction of canine coronary arterioles which is mediated by a receptor other than GHS-R1a.
      Title: Coronary vasoconstrictor effect of ghrelin is not mediated by growth hormone secretagogue receptor 1a type in dogs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ghrelin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth hormone-releasing hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to food IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    appetite-regulating hormone
    Names
    ghrelin, growth hormone secretagogue receptor ligand
    ghrelin/obestatin preprohormone
    growth hormone secretagogue
    growth hormone-releasing peptide
    motilin related peptide

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003052.2 → NP_001003052.1  appetite-regulating hormone preproprotein

      See identical proteins and their annotated locations for NP_001003052.1

      Status: VALIDATED

      Source sequence(s)
      AB060700
      UniProtKB/Swiss-Prot
      Q9BEF7, Q9BEF8
      UniProtKB/TrEMBL
      A0A8C0QXL3
      Related
      ENSCAFP00845010788.1, ENSCAFT00845013921.1
      Conserved Domains (2) summary
      pfam04643
      Location:59 → 115
      Motilin_assoc; Motilin/ghrelin-associated peptide
      pfam04644
      Location:24 → 51
      Motilin_ghrelin; Motilin/ghrelin

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      8122116..8127217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426354.1 → XP_038282282.1  appetite-regulating hormone isoform X2

      Conserved Domains (2) summary
      pfam04643
      Location:58 → 114
      Motilin_assoc; Motilin/ghrelin-associated peptide
      pfam04644
      Location:24 → 50
      Motilin_ghrelin; Motilin/ghrelin

    2. XM_038426353.1 → XP_038282281.1  appetite-regulating hormone isoform X1

      UniProtKB/Swiss-Prot
      Q9BEF7, Q9BEF8
      UniProtKB/TrEMBL
      A0A8C0QXL3
      Conserved Domains (2) summary
      pfam04643
      Location:59 → 115
      Motilin_assoc; Motilin/ghrelin-associated peptide
      pfam04644
      Location:24 → 51
      Motilin_ghrelin; Motilin/ghrelin

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      7844540..7849093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      8190266..8194819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      8163907..8168460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      8127316..8131869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BEF8.1 GenPept UniProtKB/Swiss-Prot:Q9BEF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.