LIF LIF interleukin 6 family cytokine [Sus scrofa (pig)] - Gene

Summary

Official Symbol: LIFprovided by VGNC
Official Full Name: LIF interleukin 6 family cytokineprovided by VGNC
Primary source: VGNC:VGNC:89719
See related: Ensembl:ENSSSCG00000040961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	14	NC_010456.5 (47221540..47239513, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	14	NC_010456.4 (50263470..50277784, complement)

Chromosome 14 - NC_010456.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Title: Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
Title: Leukemia inhibitory factor promotes porcine oocyte maturation and is accompanied by activation of signal transducer and activator of transcription 3.
LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Title: Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
Title: Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
The results indicated that the B allele at SNP locus LIF1 and the A allele at SNP locus LIF2 seem to have advantageous effects on litter size.
Title: Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs.
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines
Title: Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines.
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
Title: Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
Title: Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line.

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General gene information

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Markers

LIF (e-PCR), detects polymorphism
- UniSTS:253524

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables leukemia inhibitory factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leukemia inhibitory factor

Names: leukemia inhibitory factor (cholinergic differentiation factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.