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    PTH parathyroid hormone [ Sus scrofa (pig) ]

    Gene ID: 399502, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PTHprovided by VGNC
    Official Full Name
    parathyroid hormoneprovided by VGNC
    Primary source
    VGNC:VGNC:91960
    See related
    Ensembl:ENSSSCG00000013394
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (45757398..45760433)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (49290017..49290981, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene spondin 1 Neighboring gene fatty acyl-CoA reductase 1 Neighboring gene BTB domain containing 10 Neighboring gene aryl hydrocarbon receptor nuclear translocator like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. Zierold C, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11698670, Free PMC Article
    2. Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. Fukayama S, et al. Am J Physiol, 1996 Jul. PMID 8760037
    3. The amino acid sequence of porcine parathyroid hormone. Sauer RT, et al. Biochemistry, 1974 Apr 23. PMID 4840833
    4. Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence. Chu LK, et al. Biochemistry, 1975 Aug 12. PMID 1164500
    5. Regulation of the procine 1,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 and parathyroid hormone in AOK-B50 cells. Zierold C, et al. Arch Biochem Biophys, 2000 Sep 15. PMID 11032422

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables parathyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    parathyroid hormone
    Names
    parathyrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214401.1 → NP_999566.1  parathyroid hormone precursor

      See identical proteins and their annotated locations for NP_999566.1

      Status: PROVISIONAL

      Source sequence(s)
      X05722
      UniProtKB/Swiss-Prot
      P01269
      UniProtKB/TrEMBL
      A0A8D1Z9A5
      Related
      ENSSSCP00000014236.3, ENSSSCT00000014631.3
      Conserved Domains (1) summary
      smart00087
      Location:30 → 65
      PTH; Parathyroid hormone

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      45757398..45760433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021081593.1 → XP_020937252.1  parathyroid hormone isoform X1

      UniProtKB/Swiss-Prot
      P01269
      UniProtKB/TrEMBL
      A0A8D1Z9A5
      Conserved Domains (1) summary
      smart00087
      Location:30 → 65
      PTH; Parathyroid hormone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01269.1 GenPept UniProtKB/Swiss-Prot:P01269

    Gene LinkOut

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