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    bcar1.L BCAR1, Cas family scaffold protein L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398756, updated on 11-Apr-2024

    Summary

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    Official Symbol
    bcar1.L
    Official Full Name
    BCAR1, Cas family scaffold protein L homeolog
    Primary source
    Xenbase:XB-GENE-955193
    Locus tag
    XELAEV_18022493mg
    See related
    EnsemblRapid:ENSXLAG00005017692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    bcar1; CASB3b; p130Cas
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    Genomic context

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    Location:
    chromosome: 4L
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (41029164..41109604, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (38522332..38603214, complement)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC subunit 6 L homeolog Neighboring gene hydroxysteroid dehydrogenase like 1 L homeolog Neighboring gene craniofacial development protein 1 L homeolog Neighboring gene uncharacterized LOC108714007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development. Green YS, et al. Gene Expr Patterns, 2016 Jan. PMID 26631802, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC68466

    Gene Ontology Provided by Xenbase

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BCAR1, Cas family scaffold protein L homeolog
    Names
    breast cancer anti-estrogen resistance 1 L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089651.1 → NP_001083120.1  BCAR1, Cas family scaffold protein L homeolog

      See identical proteins and their annotated locations for NP_001083120.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060334
      UniProtKB/TrEMBL
      A0A974D2H4, Q6PAF8
      Related
      ENSXLAP00005052218.1, ENSXLAT00005053382.1
      Conserved Domains (3) summary
      cd11552
      Location:523 → 680
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:4 → 70
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam12026
      Location:737 → 945
      DUF3513; Domain of unknown function (DUF3513)

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      41029164..41109604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018256557.2 → XP_018112046.1  BCAR1, Cas family scaffold protein L homeolog isoform X3

      UniProtKB/TrEMBL
      A0A8J0USV2, A0A974D2H4

    2. XM_041589216.1 → XP_041445150.1  BCAR1, Cas family scaffold protein L homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J1MVV9, A0A974D2H4
      Conserved Domains (4) summary
      cd11552
      Location:525 → 682
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd11569
      Location:788 → 920
      FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:7 → 72
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      PRK10263
      Location:115 → 240
      PRK10263; DNA translocase FtsK; Provisional

    3. XM_041589215.1 → XP_041445149.1  BCAR1, Cas family scaffold protein L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1MTI7, A0A974D2H4
      Conserved Domains (4) summary
      cd11552
      Location:525 → 682
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd11569
      Location:818 → 950
      FAT-like_BCAR1_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:7 → 72
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      PRK10263
      Location:115 → 240
      PRK10263; DNA translocase FtsK; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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