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    esr1.L estrogen receptor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398734, updated on 11-Apr-2024

    Summary

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    Official Symbol
    esr1.L
    Official Full Name
    estrogen receptor 1 L homeolog
    Primary source
    Xenbase:XB-GENE-864840
    Locus tag
    XELAEV_18026742mg
    See related
    EnsemblRapid:ENSXLAG00005016266
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ER; XER; esr; esr1; esr1a; nr3a1; xesr1; ERbeta; esr1-a; esr1-b; xesr-1; ERalpha; ER-alpha; xlERalpha1; xlERalpha2
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    Genomic context

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    Location:
    chromosome: 5L
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (49625129..49743175, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (48455744..48573461, complement)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene MYC target 1 L homeolog Neighboring gene spectrin repeat containing, nuclear envelope 1 L homeolog Neighboring gene coiled-coil domain containing 170 L homeolog Neighboring gene zinc finger and BTB domain containing 2 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An estrogen receptor mutant exhibiting hormone-independent transactivation and enhanced affinity for the estrogen response element. Xing H, et al. J Biol Chem, 1993 Nov 5. PMID 8226845
    2. The Xenopus laevis estrogen receptor: sequence homology with human and avian receptors and identification of multiple estrogen receptor messenger ribonucleic acids. Weiler IJ, et al. Mol Endocrinol, 1987 May. PMID 3274894
    3. Antagonistic role of XESR1 and XESR5 in mesoderm formation in Xenopus laevis. Kinoshita T, et al. Int J Dev Biol, 2011. PMID 21425079
    4. A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome. Tanaka K, et al. Dev Biol, 2014 Mar 1. PMID 24440151, Free PMC Article
    5. Estrogen receptor expression in laryngeal muscle in relation to estrogen-dependent increases in synapse strength. Wu KH, et al. Neuroendocrinology, 2003 Aug. PMID 12915759

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    estrogen receptor
    Names
    Estradiol receptor
    Nuclear receptor subfamily 3 group A member 1
    estrogen receptor 1 a
    estrogen receptor alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089617.1 → NP_001083086.1  estrogen receptor

      See identical proteins and their annotated locations for NP_001083086.1

      Status: PROVISIONAL

      Source sequence(s)
      AY310904
      UniProtKB/Swiss-Prot
      P81559
      UniProtKB/TrEMBL
      A0A974CUB0, Q6W5G7
      Conserved Domains (4) summary
      cd06949
      Location:301 → 538
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:174 → 255
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 175
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:547 → 585
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      49625129..49743175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041562111.1 → XP_041418045.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P81559
      UniProtKB/TrEMBL
      A0A974CUB0, Q6W5G7
      Related
      ENSXLAP00005047880.1, ENSXLAT00005048995.1
      Conserved Domains (4) summary
      cd06949
      Location:301 → 538
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:174 → 255
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 175
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:547 → 585
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81559.1 GenPept UniProtKB/Swiss-Prot:P81559

    Gene LinkOut

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