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    TIMP4 TIMP metallopeptidase inhibitor 4 [ Sus scrofa (pig) ]

    Gene ID: 396774, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TIMP4provided by VGNC
    Official Full Name
    TIMP metallopeptidase inhibitor 4provided by VGNC
    Primary source
    VGNC:VGNC:93997
    See related
    Ensembl:ENSSSCG00000033000
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    TIMP-4
    Expression
    Broad expression in subcutaneous adipose (RPKM 20.1), psoas major muscle (RPKM 6.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (68179803..68191199, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (75371793..75377933, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog Neighboring gene synapsin II Neighboring gene uncharacterized LOC106505675 Neighboring gene uncharacterized LOC106505676 Neighboring gene peroxisome proliferator activated receptor gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to organic substance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 4
    Names
    tissue inhibitor of metalloproteinase-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      68179803..68191199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021069344.1 → XP_020925003.1  metalloproteinase inhibitor 4

      UniProtKB/TrEMBL
      A0A287B188, A0A8D0JK42, A0A8D0QDC0
      Related
      ENSSSCP00000049865.1, ENSSSCT00000042009.3
      Conserved Domains (1) summary
      cd03585
      Location:30 → 211
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
    Nucleotide Protein
    Heading Accession and Version

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