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    CAPZB capping actin protein of muscle Z-line beta subunit [ Gallus gallus (chicken) ]

    Gene ID: 396418, updated on 3-Apr-2024

    Summary

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    Symbol
    CAPZBprovided by CGNC
    Full Name
    capping actin protein of muscle Z-line beta subunitprovided by CGNC
    Primary source
    CGNC:2959
    See related
    Ensembl:ENSGALG00010020608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4676817..4729683, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4710025..4762904, complement)

    Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) Neighboring gene PQ loop repeat containing 2 Neighboring gene mitochondrial inner membrane organizing system 1 Neighboring gene neuroblastoma 1, DAN family BMP antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNAs encoding the beta subunit of cap Z, the actin-capping protein of the Z line of muscle. Caldwell JE, et al. J Biol Chem, 1989 Jul 25. PMID 2745461
    2. Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. Schafer DA, et al. J Cell Biol, 1994 Oct. PMID 7929588, Free PMC Article
    3. Beta-actinin is equivalent to Cap Z protein. Maruyama K, et al. J Biol Chem, 1990 May 25. PMID 2341404
    4. Structural basis of actin filament capping at the barbed-end: a cryo-electron microscopy study. Narita A, et al. EMBO J, 2006 Nov 29. PMID 17110933, Free PMC Article
    5. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    capping protein (actin filament) muscle Z-line, beta
    Names
    F-actin-capping protein subunit beta
    actin-capping protein Z (cap-Z) beta subunit
    beta-actinin subunit II
    capZ 36/32
    capZ B1 and B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173529.2 → NP_001167000.1  capping protein (actin filament) muscle Z-line, beta isoform 2

      See identical proteins and their annotated locations for NP_001167000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000329
      UniProtKB/Swiss-Prot
      P14315
      Conserved Domains (1) summary
      pfam01115
      Location:11 → 239
      F_actin_cap_B; F-actin capping protein, beta subunit

    2. NM_205437.3 → NP_990768.1  capping protein (actin filament) muscle Z-line, beta isoform 1

      See identical proteins and their annotated locations for NP_990768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAENSK010000329
      UniProtKB/Swiss-Prot
      P14315
      UniProtKB/TrEMBL
      A0A8V0Z831
      Related
      ENSGALP00010029404.1, ENSGALT00010049763.1
      Conserved Domains (1) summary
      pfam01115
      Location:11 → 239
      F_actin_cap_B; F-actin capping protein, beta subunit

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4676817..4729683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015296835.4 → XP_015152321.1  capping protein (actin filament) muscle Z-line, beta isoform X1

      UniProtKB/Swiss-Prot
      P14315
      UniProtKB/TrEMBL
      A0A8V0Z831
      Conserved Domains (1) summary
      pfam01115
      Location:11 → 239
      F_actin_cap_B; F-actin capping protein, beta subunit

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4710025..4762904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046931166.1 → XP_046787122.1  capping protein (actin filament) muscle Z-line, beta isoform X1

      UniProtKB/Swiss-Prot
      P14315
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14315.3 GenPept UniProtKB/Swiss-Prot:P14315

    Gene LinkOut

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