C3 complement component 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: C3provided by CGNC
Official Full Name: complement component 3provided by CGNC
Primary source: CGNC:8744
See related: Ensembl:ENSGALG00010003164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: C3d
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 30

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	30	NC_052561.1 (138499..165753)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	30 Unlocalized Scaffold	NW_024096184.1 (212352..241162, complement)

Chromosome 30 - NC_052561.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C3a is sufficient to induce complete regeneration of the embryonic chick retina from stem/progenitor cells present in the eye, independent of fibroblast growth factor receptor signaling.
Title: Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
Complement C1 Inactivator Proteins, in addition to inhibition of the systemic complement activation, prevents myocardial cell injury via a direct inhibitory role in the local myocardial C3 activity
Title: Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity.
C3 is transported into oocytes by LR8-mediated endocytosis.
Title: Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: complement C3

Names: complement C3 alpha chain; complement component 3d

NP_001383072.1

EC 3.4.21.43

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396143.1 → NP_001383072.1 complement C3 precursor

Status: VALIDATED

Source sequence(s)

AM064975, AM066546, BG641760, BG641952, BM490260, BU242218, BU248855, BU457016, DQ291160, JAENSK010000387, U16848

UniProtKB/TrEMBL

Q90633

Related

ENSGALP00010004446.1, ENSGALT00010007429.1

Conserved Domains (4) summary

COG2373
Location:127 → 267

YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]

cd00017
Location:672 → 738

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:987 → 1270

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

cd03583
Location:1501 → 1650

NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052561.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

138499..165753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NW_024096184.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

212352..241162 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_205405.3: Suppressed sequence

Description

NM_205405.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.