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    aldh2.1 aldehyde dehydrogenase 2 family member, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393462, updated on 27-Mar-2024

    Summary

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    Official Symbol
    aldh2.1provided by ZNC
    Official Full Name
    aldehyde dehydrogenase 2 family member, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1262
    See related
    Ensembl:ENSDARG00000089924 AllianceGenome:ZFIN:ZDB-GENE-040426-1262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aldh2; aldh2a; zgc:63786
    Summary
    Enables 3-chloroallyl aldehyde dehydrogenase activity. Predicted to act upstream of or within cellular aldehyde metabolic process. Is expressed in several structures, including fin; heart; liver; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69574673..69595487, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (68802121..68822935, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene KISS1 receptor b Neighboring gene MAPK activated protein kinase 5 Neighboring gene aldehyde dehydrogenase 2 family member, tandem duplicate 2 Neighboring gene VPS33A core subunit of CORVET and HOPS complexes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Wohlfart DP, et al. Redox Biol, 2022 Apr. PMID 35114580, Free PMC Article
    2. Molecular cloning and expression of a second zebrafish aldehyde dehydrogenase 2 gene (aldh2b). Song W, et al. DNA Seq, 2006 Aug. PMID 17312945
    3. Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Lassen N, et al. Drug Metab Dispos, 2005 May. PMID 15703303
    4. Is retinoic acid genetic machinery a chordate innovation? Cañestro C, et al. Evol Dev, 2006 Sep-Oct. PMID 16925675
    5. Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts. Pittlik S, et al. Gene Expr Patterns, 2008 Feb. PMID 18178530

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.
      Title: Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63786

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase 2 family member, tandem duplicate 1
    Names
    aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1
    aldehyde dehydrogenase 2 family (mitochondrial)a
    aldehyde dehydrogenase 2, tandem duplicate 1
    aldehyde dehydrogenase 2.1
    NP_956784.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200490.1 → NP_956784.1  aldehyde dehydrogenase 2 family member, tandem duplicate 1

      See identical proteins and their annotated locations for NP_956784.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055244
      UniProtKB/TrEMBL
      Q7SXU3
      Related
      ENSDARP00000012767.8, ENSDART00000016808.9
      Conserved Domains (1) summary
      cd07141
      Location:30 → 510
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      69574673..69595487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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