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    INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 388324, updated on 5-Mar-2024

    Summary

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    Official Symbol
    INCA1provided by HGNC
    Official Full Name
    inhibitor of CDK, cyclin A1 interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:32224
    See related
    Ensembl:ENSG00000196388 MIM:617374; AllianceGenome:HGNC:32224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSD45
    Summary
    Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INCA1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4988130..4997522, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4878461..4887846, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4891425..4900817, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903901 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene microRNA 6865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8059 Neighboring gene CAMTA2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4902950-4903561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4903562-4904172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4906716-4907915 Neighboring gene kinesin family member 1C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8063 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4923264-4924463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4925730-4926294 Neighboring gene KIF1C antisense RNA 1 Neighboring gene uncharacterized LOC105371501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11564 Neighboring gene solute carrier family 52 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. Kang S, et al. J Biol Chem, 2005 Nov 11. PMID 16148011
    2. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. Li XB, et al. Mol Med Rep, 2011 Nov-Dec. PMID 21874239
    3. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Chen X, et al. Biochem Cell Biol, 2008 Aug. PMID 18756329
    4. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, et al. Int J Cancer, 2005 Aug 20. PMID 15800920
    5. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. Bäumer N, et al. J Biol Chem, 2011 Aug 12. PMID 21540187, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling
      Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.
    2. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.
      Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148150, MGC148151

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein INCA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167985.2 → NP_001161457.1  protein INCA1 isoform 2

      See identical proteins and their annotated locations for NP_001161457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AY601907, AY604176
      Consensus CDS
      CCDS11064.1
      UniProtKB/Swiss-Prot
      Q0VD86
      Related
      ENSP00000461844.1, ENST00000575780.5
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 175
      INCA1

    2. NM_001167986.2 → NP_001161458.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001161458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY601906, AY604176, BC119781
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6J273, Q6PKN9
      Related
      ENSP00000458316.1, ENST00000574617.1
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 190
      INCA1

    3. NM_001167987.2 → NP_001161459.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001161459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY601906, AY604176, BC122873
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6J273, Q6PKN9
      Related
      ENSP00000460673.1, ENST00000576820.5
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 190
      INCA1

    4. NM_001394788.1 → NP_001381717.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6J273, Q6PKN9
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 190
      INCA1

    5. NM_001394789.1 → NP_001381718.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS54074.1
      UniProtKB/Swiss-Prot
      Q0VD86, Q6J273, Q6PKN9
      Related
      ENSP00000511805.1, ENST00000695324.1
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 190
      INCA1

    6. NM_001394790.1 → NP_001381719.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11064.1
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 175
      INCA1

    7. NM_001394791.1 → NP_001381720.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11064.1
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 175
      INCA1

    8. NM_213726.3 → NP_998891.2  protein INCA1 isoform 2

      See identical proteins and their annotated locations for NP_998891.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AY601906, AY604176
      Consensus CDS
      CCDS11064.1
      UniProtKB/Swiss-Prot
      Q0VD86
      Related
      ENSP00000347129.3, ENST00000355025.7
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 175
      INCA1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4988130..4997522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256628.6 → XP_005256685.1  protein INCA1 isoform X1

      See identical proteins and their annotated locations for XP_005256685.1

      UniProtKB/Swiss-Prot
      Q0VD86, Q6J273, Q6PKN9
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 190
      INCA1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4878461..4887846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316026.1 → XP_054172001.1  protein INCA1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VD86.1 GenPept UniProtKB/Swiss-Prot:Q0VD86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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