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    crhr2.S corticotropin releasing hormone receptor 2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 378608, updated on 11-Apr-2024

    Summary

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    Official Symbol
    crhr2.S
    Official Full Name
    corticotropin releasing hormone receptor 2 S homeolog
    Primary source
    Xenbase:XB-GENE-990954
    Locus tag
    XELAEV_18032785mg
    See related
    EnsemblRapid:ENSXLAG00005031687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    CRF2; crfr2; crhr2; crhr2-A
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    Genomic context

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    Location:
    chromosome: 6S
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (6826396..6973573)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (6506500..6569352)

    Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene proteasome maturation protein S homeolog Neighboring gene uncharacterized LOC108719656 Neighboring gene glycyl-tRNA synthetase 1 S homeolog Neighboring gene uncharacterized LOC121395224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two corticotropin-releasing factor receptors from Xenopus laevis with high ligand selectivity: unusual pharmacology of the type 1 receptor. Dautzenberg FM, et al. J Neurochem, 1997 Oct. PMID 9326293

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corticotrophin-releasing factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corticotropin-releasing hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    corticotropin-releasing factor receptor 2
    Names
    CRF-R-2
    CRF-R2
    CRFR-2
    CRH-R-2
    CRH-R2
    corticotropin-releasing hormone receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085831.1 → NP_001079300.1  corticotropin-releasing factor receptor 2 precursor

      See identical proteins and their annotated locations for NP_001079300.1

      Status: PROVISIONAL

      Source sequence(s)
      Y14037
      UniProtKB/Swiss-Prot
      O42603
      UniProtKB/TrEMBL
      A0A974CJI4
      Related
      ENSXLAP00005094918.1, ENSXLAT00005096630.1
      Conserved Domains (2) summary
      pfam00002
      Location:120 → 357
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:40 → 104
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      6826396..6973573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018268553.2 → XP_018124042.2  corticotropin-releasing factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8J0VIK5, A0A974CJI4
      Related
      ENSXLAP00005094987.1, ENSXLAT00005096704.1
      Conserved Domains (2) summary
      smart00008
      Location:42 → 113
      HormR; Domain present in hormone receptors
      cd15446
      Location:118 → 381
      7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42603.1 GenPept UniProtKB/Swiss-Prot:O42603

    Gene LinkOut

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