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    dcc.L DCC netrin 1 receptor L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 378529, updated on 11-Apr-2024

    Summary

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    Official Symbol
    dcc.L
    Official Full Name
    DCC netrin 1 receptor L homeolog
    Primary source
    Xenbase:XB-GENE-5872596
    Locus tag
    XELAEV_18008434mg
    See related
    EnsemblRapid:ENSXLAG00005028942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    dcc; xdcc; CRC18; CRCR1; XDCCa; dcc-a; dcc-b; dcca-A; igdcc1
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    Location:
    chromosome: 1L
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (221684186..221976984, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (208464998..208758391, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121395804 Neighboring gene methyl-CpG binding domain protein 2 L homeolog Neighboring gene tubulin monoglycylase TTLL3 Neighboring gene uncharacterized LOC121401470

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis. Konopacki FA, et al. Open Biol, 2016 Apr. PMID 27248654, Free PMC Article
    2. Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Pierceall WE, et al. Dev Biol, 1994 Dec. PMID 7813784
    3. Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Ugai H, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527412
    4. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Hu G, et al. Genes Dev, 1997 Oct 15. PMID 9334332, Free PMC Article
    5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT-II-mediated endocytic pathway regulates both DCC and local protein synthesis.
      Title: ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deleted in colorectal carcinoma
    Names
    deleted in colorectal cancer tumor suppressor
    deleted in colorectal carcinoma L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085785.1 → NP_001079254.1  deleted in colorectal carcinoma

      See identical proteins and their annotated locations for NP_001079254.1

      Status: PROVISIONAL

      Source sequence(s)
      U10986
      UniProtKB/TrEMBL
      B7ZRF1, Q91562
      Related
      ENSXLAP00005086381.1, ENSXLAT00005088043.1
      Conserved Domains (8) summary
      cd05722
      Location:41 → 136
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00408
      Location:154 → 217
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:726 → 805
      FN3; Fibronectin type 3 domain
      smart00410
      Location:46 → 136
      IG_like; Immunoglobulin like
      cd00063
      Location:528 → 617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:241 → 329
      I-set; Immunoglobulin I-set domain
      pfam06583
      Location:1130 → 1425
      Neogenin_C; Neogenin C-terminus
      cl11960
      Location:347 → 417
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      221684186..221976984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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