MID1 midline 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MID1provided by CGNC
Full Name: midline 1provided by CGNC
Primary source: CGNC:48957
See related: Ensembl:ENSGALG00010002012
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (124646339..124888022)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (124601466..124843246)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of Mid1 function in r2 elevates PP2Ac protein, whilst ectopic expression of Mid1 depletes PP2Ac protein.
Title: Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis.
A mutually repressive relationship between Mid1 and Shh in Hensen's node plays a key role in establishing the avian left-right axis.
Title: Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase Midline-1

Names: midline 1 (Opitz/BBB syndrome)

NP_001384590.1

EC 2.3.2.27

NP_001384591.1

EC 2.3.2.27

NP_001384592.1

EC 2.3.2.27

NP_001384593.1

EC 2.3.2.27

NP_001384594.1

EC 2.3.2.27

NP_989460.2

EC 2.3.2.27

XP_025004304.2

EC 2.3.2.27

XP_025004317.2

EC 2.3.2.27

XP_025004353.2

EC 2.3.2.27

XP_040552626.1

EC 2.3.2.27

XP_046762229.1

EC 2.3.2.27

XP_046762230.1

EC 2.3.2.27

XP_046762231.1

EC 2.3.2.27

XP_046762233.1

EC 2.3.2.27

XP_046762234.1

EC 2.3.2.27

XP_046794869.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397661.1 → NP_001384590.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

Q90WD1

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001397662.1 → NP_001384591.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

Q90WD1

Related

ENSGALP00010002778.1, ENSGALT00010004571.1

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001397663.1 → NP_001384592.1 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

Q90WD1

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
NM_001397664.1 → NP_001384593.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

A0A8V0X812

Conserved Domains (6) summary

smart00502
Location:251 → 372

BBC; B-Box C-terminal domain

cd00063
Location:409 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:513 → 689

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
NM_001397665.1 → NP_001384594.1 E3 ubiquitin-protein ligase Midline-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

A0A8V0X812

Related

ENSGALP00010002773.1, ENSGALT00010004561.1

Conserved Domains (6) summary

smart00502
Location:251 → 372

BBC; B-Box C-terminal domain

cd00063
Location:409 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:513 → 689

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
NM_204129.2 → NP_989460.2 E3 ubiquitin-protein ligase Midline-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000024

UniProtKB/TrEMBL

Q90WD1

Related

ENSGALP00010002776.1, ENSGALT00010004567.1

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

124646339..124888022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025148536.3 → XP_025004304.2 E3 ubiquitin-protein ligase Midline-1 isoform X1

UniProtKB/TrEMBL

A0A8V0X812, A0A8V0XB44

Conserved Domains (6) summary

smart00502
Location:251 → 372

BBC; B-Box C-terminal domain

cd00063
Location:409 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:513 → 689

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
XM_025148585.3 → XP_025004353.2 E3 ubiquitin-protein ligase Midline-1 isoform X1

UniProtKB/TrEMBL

A0A8V0X812, A0A8V0XB44

Conserved Domains (6) summary

smart00502
Location:251 → 372

BBC; B-Box C-terminal domain

cd00063
Location:409 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:513 → 689

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
XM_040696692.2 → XP_040552626.1 E3 ubiquitin-protein ligase Midline-1 isoform X2

UniProtKB/TrEMBL

A0A8V0XB44, Q90WD1

Conserved Domains (7) summary

smart00502
Location:219 → 344

BBC; B-Box C-terminal domain

cd00063
Location:381 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:485 → 661

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins

pfam18568
Location:323 → 374

COS; TRIM C-terminal subgroup One Signature domain
XM_025148549.3 → XP_025004317.2 E3 ubiquitin-protein ligase Midline-1 isoform X1

UniProtKB/TrEMBL

A0A8V0X812, A0A8V0XB44

Conserved Domains (6) summary

smart00502
Location:251 → 372

BBC; B-Box C-terminal domain

cd00063
Location:409 → 509

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12892
Location:513 → 689

SPRY_PRY_TRIM18; PRY/SPRY domain of TRIM18/MID1, also known as FXY or RNF59

cd16753
Location:8 → 61

RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins

cd19822
Location:168 → 214

Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins

cd19836
Location:115 → 164

Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
XM_046938913.1 → XP_046794869.1 E3 ubiquitin-protein ligase Midline-1 isoform X1

UniProtKB/TrEMBL

A0A8V0X812

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

124601466..124843246

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046906274.1 → XP_046762230.1 E3 ubiquitin-protein ligase Midline-1 isoform X1
XM_046906275.1 → XP_046762231.1 E3 ubiquitin-protein ligase Midline-1 isoform X1
XM_046906278.1 → XP_046762234.1 E3 ubiquitin-protein ligase Midline-1 isoform X2

UniProtKB/TrEMBL

A0A1D5PG57, Q71R46
XM_046906273.1 → XP_046762229.1 E3 ubiquitin-protein ligase Midline-1 isoform X1
XM_046906277.1 → XP_046762233.1 E3 ubiquitin-protein ligase Midline-1 isoform X1