lrp5.L LDL receptor related protein 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lrp5.L
Official Full Name: LDL receptor related protein 5 L homeolog
Primary source: Xenbase:XB-GENE-864864
Locus tag: XELAEV_18022268mg
See related: EnsemblRapid:ENSXLAG00005018498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hbm; lr3; ops; evr1; evr4; lrp5; lrp7; oppg; Xlrp5; bmnd1; opta1; vbch2; lrp5-A
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Genomic context

Location:: chromosome: 4L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (28348596..28465847, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (26829101..26946490, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016727194.1 (217..557)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.
Title: The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone marrow development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LDL receptor related protein 5 L homeolog

Names: low density lipoprotein receptor-related protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085694.1 → NP_001079163.1 LDL receptor related protein 5 L homeolog precursor

See identical proteins and their annotated locations for NP_001079163.1

Status: PROVISIONAL

Source sequence(s)

AF508960

UniProtKB/TrEMBL

A0A974D216, Q8AYF1

Related

ENSXLAP00005054728.1, ENSXLAT00005055908.1

Conserved Domains (6) summary

smart00135
Location:398 → 440

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1290 → 1324

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:95 → 136

NHL; NHL repeat [structural motif]

pfam00058
Location:151 → 191

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:595 → 630

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl18310
Location:26 → 157

NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

28348596..28465847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589121.1 → XP_041445055.1 LDL receptor related protein 5 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MVJ8, A0A974D216

Conserved Domains (2) summary

smart00135
Location:396 → 438

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1303 → 1337

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_041589122.1 → XP_041445056.1 LDL receptor related protein 5 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1MUB6, A0A974D216

Related

ENSXLAP00005054716.1, ENSXLAT00005055895.1

Conserved Domains (2) summary

smart00135
Location:71 → 113

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1286 → 1320

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...