cflara CASP8 and FADD-like apoptosis regulator a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cflaraprovided by ZNC
Official Full Name: CASP8 and FADD-like apoptosis regulator aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-3
See related: Ensembl:ENSDARG00000055966 AllianceGenome:ZFIN:ZDB-GENE-030826-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: FLIP; cflar; Clarp1
Summary: Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (30332458..30341431, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (30085775..30094247, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CASP8 and FADD-like apoptosis regulator a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313772.1 → NP_001300701.1 CASP8 and FADD-like apoptosis regulator a

Status: VALIDATED

Source sequence(s)

BX323548, EH552705, EH554609, EH575723

UniProtKB/TrEMBL

A0A8M1P2J9, F1R706

Related

ENSDARP00000072840.2, ENSDART00000078378.5

Conserved Domains (3) summary

cd08340
Location:100 → 180

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

pfam01335
Location:8 → 87

DED; Death effector domain

cl00042
Location:241 → 461

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

30332458..30341431 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479557.1 → XP_021335232.1 CASP8 and FADD-like apoptosis regulator a isoform X1

UniProtKB/TrEMBL

A0A8M1P2J9, F1R706

Conserved Domains (3) summary

cd08340
Location:100 → 180

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

pfam01335
Location:8 → 87

DED; Death effector domain

cl00042
Location:241 → 461

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...