Hyal1 hyaluronidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hyal1provided by RGD
Official Full Name: hyaluronidase 1provided by RGD
Primary source: RGD:1303060
See related: Ensembl:ENSRNOG00000015858 AllianceGenome:RGD:1303060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hyaluronan synthase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; hyaluronan metabolic process; and regulation of cell growth. Predicted to act upstream of or within embryonic skeletal joint morphogenesis. Predicted to be located in extracellular space; hyaluranon cable; and lysosome. Predicted to be active in cytoplasmic vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 738.2), Kidney (RPKM 175.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117129311..117133162)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108250668..108254519)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116332834..116337522)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2).
Title: Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2).
Association of hyaluronidases 1/2 expresion with neurons in the infarcted and peri-infarcted regions of the middle cerebral artery.
Title: Hyaluronan expression following middle cerebral artery occlusion in the rat.

Submit: New GeneRIF Correction

General gene information

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Markers

Hyal1 (e-PCR), detects polymorphism
- UniSTS:526011

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chondroitin hydrolase activity	IEA Inferred from Electronic Annotation more info
enables chondroitin hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hyaluronan synthase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	ISO Inferred from Sequence Orthology more info
enables hyaluronan synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hyalurononglucosaminidase activity	IEA Inferred from Electronic Annotation more info
NOT enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
NOT enables virus receptor activity	ISO Inferred from Sequence Orthology more info
NOT enables virus receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal joint morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hyaluranon cable assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hyaluranon cable assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluranon cable assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in hyaluranon cable	IEA Inferred from Electronic Annotation more info
located_in hyaluranon cable	ISO Inferred from Sequence Orthology more info
located_in hyaluranon cable	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hyaluronidase-1

Names: hyal-1; hyaluronoglucosaminidase 1

NP_001399428.1

EC 3.2.1.35

NP_997499.2

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412499.1 → NP_001399428.1 hyaluronidase-1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_207616.2 → NP_997499.2 hyaluronidase-1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I2Y4

Related

ENSRNOP00000091439.1, ENSRNOT00000107744.1