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    Ack-like Activated Cdc42 kinase-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36442, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ack-likeprovided by FlyBase
    Official Full Name
    Activated Cdc42 kinase-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263998
    Locus tag
    Dmel_CG43741
    See related
    AllianceGenome:FB:FBgn0263998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33007; CG3969; CG43741; dACK; Dmel\CG43741; DmHD-11; DPR2; DRODPR2; HD-11; PR2; PR2/ACK; Rp2
    Old locus tag
    Dmel_CG33007; Dmel_CG3969
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in dorsal closure, amnioserosa morphology change; head involution; and myosin filament assembly. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including embryonic epidermis; embryonic/larval dorsal vessel; embryonic/larval nervous system; extended germ band embryo; and germ layer. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    49F3-49F4; 2-68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13142834..13152677, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9030339..9040182, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome associated protein G Neighboring gene Tripeptidyl-peptidase II Neighboring gene NADH dehydrogenase (ubiquinone) MWFE subunit Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog. Ito M, et al. Gene, 1994 Feb 25. PMID 8112607
    2. An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior. Dean KE, et al. PLoS One, 2013. PMID 24376789, Free PMC Article
    3. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. Burbelo PD, et al. J Biol Chem, 1995 Dec 8. PMID 7493928
    4. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Sem KP, et al. Mol Cell Biol, 2002 Jun. PMID 11997505, Free PMC Article
    5. Modulation of morphogenesis by Egfr during dorsal closure in Drosophila. Shen W, et al. PLoS One, 2013. PMID 23579691, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal closure, amnioserosa morphology change IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in head involution IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myosin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activated Cdc42 kinase-like
    Names
    Ack-like-PA
    Ack-like-PC
    Ack-like-PD
    Ack-like-PE
    CG43741-PA
    CG43741-PC
    CG43741-PD
    CG43741-PE
    Fak-like tyrosine kinase
    tyrosine kinase
    NP_001260934.1
    NP_001260935.1
    NP_477086.2
    NP_477087.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13142834..13152677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057738.4 → NP_477086.2  activated Cdc42 kinase-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477086.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24316, Q960Z6, Q9I7F7, Q9V6K0
      Related
      FBpp0303361
      Conserved Domains (5) summary
      cd09539
      Location:4 → 65
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:133 → 396
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:400 → 454
      SH3; Src homology 3 domains
      cd00132
      Location:486 → 525
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd05040
      Location:137 → 398
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    2. NM_057739.4 → NP_477087.3  activated Cdc42 kinase-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477087.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7F7
      Conserved Domains (5) summary
      cd09539
      Location:4 → 65
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:133 → 396
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:400 → 454
      SH3; Src homology 3 domains
      cd00132
      Location:486 → 525
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd05040
      Location:137 → 398
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    3. NM_001274006.1 → NP_001260935.1  activated Cdc42 kinase-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFU0
      Conserved Domains (5) summary
      cd09539
      Location:4 → 65
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:133 → 396
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:400 → 454
      SH3; Src homology 3 domains
      cd00132
      Location:486 → 525
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd05040
      Location:137 → 398
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    4. NM_001274005.1 → NP_001260934.1  activated Cdc42 kinase-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEY9
      Conserved Domains (5) summary
      cd09539
      Location:4 → 65
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:133 → 396
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:400 → 454
      SH3; Src homology 3 domains
      cd00132
      Location:486 → 525
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd05040
      Location:137 → 398
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEY9 A0A0B4KEY9
    A0A0B4KFU0 A0A0B4KFU0
    Q9I7F7.3 Q9I7F7

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