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    Obsl1 obscurin like cytoskeletal adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363259, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Obsl1provided by RGD
    Official Full Name
    obscurin like cytoskeletal adaptor 1provided by RGD
    Primary source
    RGD:1306073
    See related
    Ensembl:ENSRNOG00000015346 AllianceGenome:RGD:1306073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306073
    Summary
    Involved in Golgi organization and positive regulation of dendrite morphogenesis. Predicted to be located in Golgi apparatus; centrosome; and perinuclear region of cytoplasm. Predicted to be part of 3M complex. Predicted to be active in synapse. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human OBSL1 (obscurin like cytoskeletal adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 153.6), Muscle (RPKM 95.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q33
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84416447..84442415, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76967802..76993771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82673871..82699577, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094714 Neighboring gene acid sensing ion channel subunit family member 4 Neighboring gene uncharacterized LOC134480596 Neighboring gene chondroitin polymerizing factor Neighboring gene transmembrane protein 198 Neighboring gene inhibin subunit alpha Neighboring gene serine/threonine kinase 11 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. Fukuzawa A, et al. J Cell Sci, 2008 Jun 1. PMID 18477606
    2. Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Geisler SB, et al. Genomics, 2007 Apr. PMID 17289344, Free PMC Article
    3. The 3M complex maintains microtubule and genome integrity. Yan J, et al. Mol Cell, 2014 Jun 5. PMID 24793695, Free PMC Article
    4. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. Litterman N, et al. PLoS Biol, 2011 May. PMID 21572988, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OBSL1 is a critical regulator of Cul7 (cullin 7) in Golgi morphogenesis and dendrite elaboration.
      Title: An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
    2. OBSL1 is expressed in a broad range of tissues and localizes to the intercalated discs, to the perinuclear region, and overlying the Z lines and M bands of adult rat cardiac myocytes
      Title: Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.
    3. Titin mutations that have been linked to limb-girdle muscular dystrophy 2J (LGMD2J) or Salih myopathy weaken or abrogate titin-obscurin and titin-Obsl1 binding, and lead to obscurin mislocalization.
      Title: Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 3M complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of 3M complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    obscurin-like protein 1
    Names
    obscurin-like 1
    NP_001363949.1
    NP_001395974.1
    XP_006245366.1
    XP_017452317.1
    XP_038939822.1
    XP_038939823.1
    XP_063123490.1
    XP_343600.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377020.1 → NP_001363949.1  obscurin-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GBF5
      Related
      ENSRNOP00000084083.1, ENSRNOT00000103263.1
      Conserved Domains (6) summary
      smart00409
      Location:435 → 510
      IG; Immunoglobulin
      smart00410
      Location:134 → 226
      IG_like; Immunoglobulin like
      cd00063
      Location:518 → 602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:916 → 984
      Ig; Immunoglobulin domain
      pfam07679
      Location:12 → 88
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:257 → 336
      Ig; Immunoglobulin domain

    2. NM_001409045.1 → NP_001395974.1  obscurin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      D3ZZ80
      Related
      ENSRNOP00000020673.7, ENSRNOT00000020673.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84416447..84442415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596828.3 → XP_017452317.1  obscurin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIN9

    2. XM_063267420.1 → XP_063123490.1  obscurin-like protein 1 isoform X4

    3. XM_006245304.4 → XP_006245366.1  obscurin-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006245366.1

      UniProtKB/TrEMBL
      A0A8I6AIN9
      Conserved Domains (7) summary
      cd00096
      Location:145 → 222
      Ig; Immunoglobulin domain
      smart00408
      Location:25 → 88
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:134 → 226
      IG; Immunoglobulin
      smart00410
      Location:1089 → 1171
      IG_like; Immunoglobulin like
      cd00063
      Location:518 → 602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1270 → 1353
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1087 → 1176
      Ig; Immunoglobulin domain

    4. XM_343599.9 → XP_343600.4  obscurin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_343600.4

      UniProtKB/TrEMBL
      A0A8I6AIN9
      Conserved Domains (7) summary
      cd00096
      Location:145 → 222
      Ig; Immunoglobulin domain
      smart00408
      Location:25 → 88
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:134 → 226
      IG; Immunoglobulin
      smart00410
      Location:1180 → 1262
      IG_like; Immunoglobulin like
      cd00063
      Location:518 → 602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1361 → 1444
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1178 → 1267
      Ig; Immunoglobulin domain

    5. XM_039083895.2 → XP_038939823.1  obscurin-like protein 1 isoform X6

      Conserved Domains (5) summary
      smart00410
      Location:134 → 226
      IG_like; Immunoglobulin like
      cd00063
      Location:518 → 602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:12 → 88
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:29 → 33
      Ig; Ig strand B [structural motif]
      cl11960
      Location:257 → 336
      Ig; Immunoglobulin domain

    6. XM_039083894.2 → XP_038939822.1  obscurin-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A6JW41
      Conserved Domains (5) summary
      smart00410
      Location:134 → 226
      IG_like; Immunoglobulin like
      cd00063
      Location:518 → 602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:12 → 88
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:29 → 33
      Ig; Ig strand B [structural motif]
      cl11960
      Location:257 → 336
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZZ80.3 GenPept UniProtKB/Swiss-Prot:D3ZZ80

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