Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc18provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 18provided by RGD
Primary source: RGD:1309334
See related: Ensembl:ENSRNOG00000058156 AllianceGenome:RGD:1309334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DHHC-18
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to act upstream of or within cellular protein localization. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 118.7), Lung (RPKM 69.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151105303..151143843, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (145821534..145859989, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (151829795..151856256, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH138639 (e-PCR)
- UniSTS:220726

AW433686 (e-PCR)
- UniSTS:248647

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC18

Names: membrane-associated DHHC18 zinc finger protein; zinc finger DHHC domain-containing protein 18; zinc finger, DHHC domain containing 18; zinc finger, DHHC-type containing 18

NP_001034428.2

EC 2.3.1.225

XP_038966311.1

EC 2.3.1.225

XP_038966312.1

EC 2.3.1.225

XP_038966313.1

EC 2.3.1.225

XP_038966315.1

EC 2.3.1.225

XP_038966317.1

EC 2.3.1.225

XP_038966318.1

EC 2.3.1.225

XP_038966319.1

EC 2.3.1.225

XP_063144129.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039339.3 → NP_001034428.2 palmitoyltransferase ZDHHC18

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZYY4

Related

ENSRNOP00000084298.1, ENSRNOT00000111487.1

Conserved Domains (1) summary

cl19890
Location:106 → 320

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

151105303..151143843 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110387.2 → XP_038966315.1 palmitoyltransferase ZDHHC18 isoform X4

UniProtKB/TrEMBL

A0A8I5ZYY4

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_039110390.2 → XP_038966318.1 palmitoyltransferase ZDHHC18 isoform X6

UniProtKB/TrEMBL

A0A8I5ZYY4

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_039110385.2 → XP_038966313.1 palmitoyltransferase ZDHHC18 isoform X3

UniProtKB/TrEMBL

A0A8I5ZYY4

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_039110383.2 → XP_038966311.1 palmitoyltransferase ZDHHC18 isoform X1

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_039110384.2 → XP_038966312.1 palmitoyltransferase ZDHHC18 isoform X2

UniProtKB/TrEMBL

A0A8I5ZYY4

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_039110389.2 → XP_038966317.1 palmitoyltransferase ZDHHC18 isoform X5

UniProtKB/TrEMBL

A0A0G2K605, A0A8I5ZYY4

Related

ENSRNOP00000073628.2

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase
XM_063288059.1 → XP_063144129.1 palmitoyltransferase ZDHHC18 isoform X5

UniProtKB/TrEMBL

A0A0G2K605
XM_039110391.2 → XP_038966319.1 palmitoyltransferase ZDHHC18 isoform X7

UniProtKB/TrEMBL

A0A8I5ZUZ6, A0A8I5ZYY4

Related

ENSRNOP00000083003.1

Conserved Domains (1) summary

pfam01529
Location:189 → 312

DHHC; DHHC palmitoyltransferase