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    Reep1 receptor accessory protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362384, updated on 12-Apr-2024

    Summary

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    Official Symbol
    Reep1provided by RGD
    Official Full Name
    receptor accessory protein 1provided by RGD
    Primary source
    RGD:1305230
    See related
    Ensembl:ENSRNOG00000008481 AllianceGenome:RGD:1305230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305230
    Summary
    Predicted to enable microtubule binding activity and olfactory receptor binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization; protein insertion into membrane; and regulation of intracellular transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 5B and hereditary spastic paraplegia 31. Orthologous to human REEP1 (receptor accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 195.5), Muscle (RPKM 195.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Reep1 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105303974..105420611)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103746004..103862347)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99618622..99735329)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 3 Neighboring gene lysine demethylase 3A Neighboring gene uncharacterized LOC134486590 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene inner membrane mitochondrial protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. Park SH, et al. J Clin Invest, 2010 Apr. PMID 20200447, Free PMC Article
    2. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
    3. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. Hashimoto Y, et al. J Biol Chem, 2014 May 9. PMID 24668814, Free PMC Article
    4. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables olfactory receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor expression-enhancing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108633.2 → NP_001102103.1  receptor expression-enhancing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001102103.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IA87
      Related
      ENSRNOP00000090724.1, ENSRNOT00000111989.1
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. NM_001429156.1 → NP_001416085.1  receptor expression-enhancing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    3. NM_001429157.1 → NP_001416086.1  receptor expression-enhancing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      105303974..105420611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286282.1 → XP_063142352.1  receptor expression-enhancing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AD43

    2. XM_039107814.2 → XP_038963742.1  receptor expression-enhancing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZTG4
      Related
      ENSRNOP00000082389.1
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    3. XM_039107807.2 → XP_038963735.1  receptor expression-enhancing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam03134
      Location:28 → 103
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    4. XM_039107810.2 → XP_038963738.1  receptor expression-enhancing protein 1 isoform X4

      Conserved Domains (1) summary
      pfam03134
      Location:1 → 56
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    5. XM_039107812.2 → XP_038963740.1  receptor expression-enhancing protein 1 isoform X5

      Conserved Domains (1) summary
      pfam03134
      Location:28 → 103
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    6. XM_039107809.1 → XP_038963737.1  receptor expression-enhancing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam03134
      Location:28 → 103
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    7. XM_008762992.3 → XP_008761214.1  receptor expression-enhancing protein 1 isoform X3

      UniProtKB/TrEMBL
      D4A193
      Related
      ENSRNOP00000061062.2, ENSRNOT00000064772.2
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    8. XM_039107813.2 → XP_038963741.1  receptor expression-enhancing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GDV4
      Related
      ENSRNOP00000085476.1
      Conserved Domains (1) summary
      pfam03134
      Location:28 → 103
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    RNA

    1. XR_005503256.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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