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    Ank2 ankyrin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362036, updated on 13-Apr-2024

    Summary

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    Symbol
    Ank2provided by RGD
    Full Name
    ankyrin 2provided by RGD
    Primary source
    RGD:620156
    See related
    Ensembl:ENSRNOG00000011076 AllianceGenome:RGD:620156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ank3
    Summary
    Enables protein kinase binding activity and transmembrane transporter binding activity. A structural constituent of cytoskeleton. Involved in paranodal junction assembly and response to methylmercury. Located in several cellular components, including cytoskeleton; membrane raft; and neuron projection. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 503.8), Heart (RPKM 95.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q42
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218052555..218628414, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (215378028..215954015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (231224643..231522655, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 2 Neighboring gene calcium/calmodulin-dependent protein kinase II delta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120101096 Neighboring gene uncharacterized LOC120101097 Neighboring gene uncharacterized LOC134485962 Neighboring gene adenosylhomocysteinase-like Neighboring gene transfer RNA valine (anticodon AAC) 18 Neighboring gene uncharacterized LOC120101095 Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene zinc finger, GRF-type containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Engelhardt M, et al. Brain Struct Funct, 2013 Jul. PMID 22886464
    2. Selective disappearance of an axonal protein, 440-kDa ankyrinB, associated with neuronal degeneration induced by methylmercury. Sakaue M, et al. J Neurosci Res, 2003 Sep 15. PMID 12949909
    3. Expression and localization of brain ankyrin isoforms and related proteins during early developmental stages of rat nervous system. Kunimoto M, et al. J Neurochem, 1998 Dec. PMID 9832159
    4. Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules. Chen K, et al. J Cell Biol, 2020 Aug 3. PMID 32640013, Free PMC Article
    5. Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion. Yoshida K, et al. J Biochem, 1997 Aug. PMID 9378703

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
      Title: Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
    2. Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
      Title: Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
    3. The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins
      Title: Identification and characterization of two ankyrin-B isoforms in mammalian heart.
    4. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.
      Title: Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SA node cell to atrial cardiac muscle cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T-tubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T-tubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrial cardiac muscle cell to AV node cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrial septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in paranodal junction assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to M-band ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to methylmercury IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in paranodal junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin-2
    Names
    ankyrin 2, brain
    ankyrin 2, neuronal
    ankyrin 3, epithelial

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427159.1 → NP_001414088.1  ankyrin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218052555..218628414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282205.1 → XP_063138275.1  ankyrin-2 isoform X28

    2. XM_063282210.1 → XP_063138280.1  ankyrin-2 isoform X35

    3. XM_063282212.1 → XP_063138282.1  ankyrin-2 isoform X45

    4. XM_063282199.1 → XP_063138269.1  ankyrin-2 isoform X21

    5. XM_063282195.1 → XP_063138265.1  ankyrin-2 isoform X16

    6. XM_063282185.1 → XP_063138255.1  ankyrin-2 isoform X5

    7. XM_063282213.1 → XP_063138283.1  ankyrin-2 isoform X46

    8. XM_039104008.2 → XP_038959936.1  ankyrin-2 isoform X8

      Conserved Domains (9) summary
      smart00218
      Location:843 → 980
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1431 → 2195
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:261 → 546
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1580 → 1861
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3436 → 3519
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:287 → 318
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:618 → 670
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1201 → 1330
      UPA_2; UPA domain
      cl39094
      Location:418 → 642
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_063282182.1 → XP_063138252.1  ankyrin-2 isoform X1

    10. XM_063282202.1 → XP_063138272.1  ankyrin-2 isoform X24

    11. XM_063282198.1 → XP_063138268.1  ankyrin-2 isoform X19

    12. XM_039104025.2 → XP_038959953.1  ankyrin-2 isoform X34

      Related
      ENSRNOP00000035307.5
      Conserved Domains (10) summary
      smart00218
      Location:798 → 902
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1353 → 2117
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:87 → 392
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1502 → 1783
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3358 → 3441
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:593 → 645
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1123 → 1252
      UPA_2; UPA domain
      pfam12796
      Location:1 → 130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:342 → 617
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_063282192.1 → XP_063138262.1  ankyrin-2 isoform X13

    14. XM_039104019.2 → XP_038959947.1  ankyrin-2 isoform X20

      Conserved Domains (10) summary
      smart00218
      Location:831 → 935
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1386 → 2150
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1535 → 1816
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3391 → 3474
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1156 → 1285
      UPA_2; UPA domain
      pfam12796
      Location:1 → 130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_063282193.1 → XP_063138263.1  ankyrin-2 isoform X14

    16. XM_063282186.1 → XP_063138256.1  ankyrin-2 isoform X6

    17. XM_063282197.1 → XP_063138267.1  ankyrin-2 isoform X18

    18. XM_063282187.1 → XP_063138257.1  ankyrin-2 isoform X7

    19. XM_039103998.2 → XP_038959926.1  ankyrin-2 isoform X2

      Conserved Domains (10) summary
      smart00218
      Location:861 → 998
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1449 → 2213
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1598 → 1879
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3454 → 3537
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1219 → 1348
      UPA_2; UPA domain
      pfam12796
      Location:1 → 130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    20. XM_063282191.1 → XP_063138261.1  ankyrin-2 isoform X12

    21. XM_063282209.1 → XP_063138279.1  ankyrin-2 isoform X33

    22. XM_063282208.1 → XP_063138278.1  ankyrin-2 isoform X31

    23. XM_063282189.1 → XP_063138259.1  ankyrin-2 isoform X10

    24. XM_063282206.1 → XP_063138276.1  ankyrin-2 isoform X29

    25. XM_063282184.1 → XP_063138254.1  ankyrin-2 isoform X4

    26. XM_063282204.1 → XP_063138274.1  ankyrin-2 isoform X26

    27. XM_063282217.1 → XP_063138287.1  ankyrin-2 isoform X50

    28. XM_063282207.1 → XP_063138277.1  ankyrin-2 isoform X30

    29. XM_039104045.2 → XP_038959973.1  ankyrin-2 isoform X43

      Conserved Domains (7) summary
      smart00218
      Location:933 → 1037
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:1416 → 1499
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728 → 780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1258 → 1387
      UPA_2; UPA domain
      pfam12796
      Location:402 → 493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477 → 752
      Ank_2; Ankyrin repeats (3 copies)

    30. XM_039104044.2 → XP_038959972.1  ankyrin-2 isoform X42

      Conserved Domains (7) summary
      smart00218
      Location:945 → 1049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:1428 → 1511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728 → 780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1270 → 1399
      UPA_2; UPA domain
      pfam12796
      Location:402 → 493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477 → 752
      Ank_2; Ankyrin repeats (3 copies)

    31. XM_063282200.1 → XP_063138270.1  ankyrin-2 isoform X22

    32. XM_039104042.2 → XP_038959970.1  ankyrin-2 isoform X41

      Conserved Domains (7) summary
      smart00218
      Location:966 → 1070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1449 → 1532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1291 → 1420
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    33. XM_039104040.2 → XP_038959968.1  ankyrin-2 isoform X40

      Conserved Domains (7) summary
      smart00218
      Location:966 → 1070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1449 → 1532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1291 → 1420
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    34. XM_039104023.2 → XP_038959951.1  ankyrin-2 isoform X32

      UniProtKB/TrEMBL
      A0A0G2K6R9
      Related
      ENSRNOP00000015386.8
      Conserved Domains (9) summary
      smart00218
      Location:966 → 1070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1521 → 2285
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1670 → 1951
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3526 → 3609
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1291 → 1420
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    35. XM_039104038.2 → XP_038959966.1  ankyrin-2 isoform X39

      Conserved Domains (7) summary
      smart00218
      Location:966 → 1103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1482 → 1565
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1324 → 1453
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    36. XM_063282215.1 → XP_063138285.1  ankyrin-2 isoform X48

    37. XM_039104022.2 → XP_038959950.1  ankyrin-2 isoform X27

      UniProtKB/TrEMBL
      A0A0G2K6R9
      Related
      ENSRNOP00000073918.2
      Conserved Domains (9) summary
      smart00218
      Location:966 → 1103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:1554 → 2318
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:1703 → 1984
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:3559 → 3642
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1324 → 1453
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    38. XM_039104031.2 → XP_038959959.1  ankyrin-2 isoform X37

      Conserved Domains (7) summary
      smart00218
      Location:978 → 1115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1494 → 1577
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1336 → 1465
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    39. XM_063282194.1 → XP_063138264.1  ankyrin-2 isoform X15

    40. XM_063282188.1 → XP_063138258.1  ankyrin-2 isoform X9

    41. XM_063282211.1 → XP_063138281.1  ankyrin-2 isoform X44

    42. XM_063282201.1 → XP_063138271.1  ankyrin-2 isoform X23

    43. XM_063282203.1 → XP_063138273.1  ankyrin-2 isoform X25

    44. XM_039104034.2 → XP_038959962.1  ankyrin-2 isoform X38

      Conserved Domains (7) summary
      smart00218
      Location:981 → 1118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419 → 704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1497 → 1580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776 → 828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1339 → 1468
      UPA_2; UPA domain
      cl39094
      Location:576 → 800
      Ank_2; Ankyrin repeats (3 copies)

    45. XM_039104029.2 → XP_038959957.1  ankyrin-2 isoform X36

      Conserved Domains (7) summary
      smart00218
      Location:981 → 1118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419 → 704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1497 → 1580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776 → 828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1339 → 1468
      UPA_2; UPA domain
      cl39094
      Location:576 → 800
      Ank_2; Ankyrin repeats (3 copies)

    46. XM_063282196.1 → XP_063138266.1  ankyrin-2 isoform X17

    47. XM_063282214.1 → XP_063138284.1  ankyrin-2 isoform X47

    48. XM_063282216.1 → XP_063138286.1  ankyrin-2 isoform X49

    49. XM_063282190.1 → XP_063138260.1  ankyrin-2 isoform X11

    50. XM_063282183.1 → XP_063138253.1  ankyrin-2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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