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1: IFI35 interferon-induced protein 35 [ Homo sapiens ]

GeneID: 3430 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
IFI35provided by HGNC
Official Full Name
interferon-induced protein 35provided by HGNC
Primary Source
HGNC:5399
See related
Ensembl:ENSG00000068079; HPRD:02844; MIM:600735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFP35; FLJ21753; IFI35

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. IFP35 can interact with the bovine Tas (BTas) regulatory protein of bovine foamy virus; overexpression of IFP35 disturbs the ability of BTas to activate viral-gene transcription and inhibits viral replication.
PubMed 2. Dissociation of the IFN-induced protein IFP35 from NMI is a newly defined specific cytoplasmic event occurring during apoptosis.
PubMed 3. The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions.
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI35, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_005524.1   N-Myc interactor   NMI      HPRD    PubMed
Nmi and IFP 35 associate into a high molecular mass complex (HMMC).
  NP_005524.1   NP_004679.1   NMI      BIND    PubMed
 
  NP_005524.1   B-ATF        HPRD    PubMed
Reconstituted Complex; Two-hybrid
  BioGRID:109656   BioGRID:115792   BATF      BioGRID    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:109656   BioGRID:114561   NMI      BioGRID    PubMed

[Top][Help]General gene information

Markers

STS-AA025690(e-PCR)
Links: UniSTS:43578
A002O37(e-PCR)
Links: UniSTS:61757
D17S1328(e-PCR)
Links: UniSTS:150085
D17S1224(e-PCR)
Links: UniSTS:149837
G30666(e-PCR)
Links: UniSTS:39512
HSC1IB122(e-PCR)
Links: UniSTS:2505
IFI35_8415(e-PCR)
Links: UniSTS:468477

Homology

Homologs of the IFI35 gene The IFI35 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.


Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function Evidence
protein binding IPI PubMed
Process Evidence
immune response NAS   
response to virus NAS   
Component Evidence
nucleus IDA PubMed

[Top][Help]General protein information

Preferred Names
interferon-induced protein 35
Names
interferon-induced protein 35

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_005533.3 → NP_005524.1  interferon-induced protein 35

    Source sequence(s)
    AA827287,BC001356,BM050205,BM748764
    Consensus CDS
    CCDS11450.1
    UniProtKB/Swiss-Prot
    P80217
    Conserved Domains (2) summary
    pfam07292
    Location:81 – 172
    Blast Score: 361
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:12 – 80
    Blast Score: 186
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000017.10

    Range
    41158768..41166475
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_010783.15 

    Range
    6432920..6440627
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000060.1

    Range
    37815040..37822745
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_926828.1 

    Range
    4686231..4693936
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000149.1

    Range
    36924533..36932236, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838436.2 

    Range
    231488..239191, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC055866.19  (191097..198745)   None
  genomic   CH471152.1   EAW60914.1
       EAW60915.1
       EAW60916.1
  genomic   L78833.1   AAC37597.1
  mRNA   AA827287.1   None
  mRNA   AK025406.1   None
  mRNA   BC001356.2   AAH01356.1
  mRNA   BM050205.1   None
  mRNA   BM748764.1   None
  mRNA   U72882.1   AAB61703.1
  other-genetic   DQ892598.2   ABM83524.1
  other-genetic   DQ895826.2   ABM86752.1
Protein Accession   Links
P80217.4   GenPept   UniProtKB/Swiss-Prot:P80217

[Top][Help]Additional Links

Gene LinkOut

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