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    TRIML1 tripartite motif family like 1 [ Homo sapiens (human) ]

    Gene ID: 339976, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIML1provided by HGNC
    Official Full Name
    tripartite motif family like 1provided by HGNC
    Primary source
    HGNC:HGNC:26698
    See related
    Ensembl:ENSG00000184108 AllianceGenome:HGNC:26698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF209
    Summary
    The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
    Expression
    Restricted expression toward testis (RPKM 5.0) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q35.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (188137229..188150767)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (191484912..191498442)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189060595..189068897)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif family like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189027714-189028231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189028751-189029269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189029270-189029788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189033421-189033938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189033939-189034456 Neighboring gene FAU pseudogene 3 Neighboring gene uncharacterized LOC107986337 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:189047967-189049166 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:189080404-189081603 Neighboring gene long intergenic non-protein coding RNA 2434 Neighboring gene uncharacterized LOC105377607

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. Tian L, et al. Mol Reprod Dev, 2009 Jul. PMID 19156909
    2. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Ji Y, et al. Br J Clin Pharmacol, 2014 Aug. PMID 24528284, Free PMC Article
    3. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
    4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Woodsmith J, et al. Mol Cell Proteomics, 2012 Jul. PMID 22493164, Free PMC Article
    5. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper describes the mouse ortholog of the human TRIML1 gene.
      Title: Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36180, MGC138638, MGC138639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase TRIML1
    Names
    RING finger protein 209
    RING-type E3 ubiquitin transferase TRIML1
    NP_848651.2
    XP_006714270.1
    XP_011530221.1
    XP_024309796.1
    XP_054205900.1
    XP_054205901.1
    XP_054205902.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051631.1 RefSeqGene

      Range
      6253..14555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178556.5 → NP_848651.2  probable E3 ubiquitin-protein ligase TRIML1

      See identical proteins and their annotated locations for NP_848651.2

      Status: REVIEWED

      Source sequence(s)
      AK093499, BC015684, DB058735
      Consensus CDS
      CCDS3851.1
      UniProtKB/Swiss-Prot
      Q8N9V2, Q96BE5
      Related
      ENSP00000327738.3, ENST00000332517.4
      Conserved Domains (3) summary
      pfam10249
      Location:130 → 184
      NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd13733
      Location:287 → 462
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      188137229..188150767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454028.1 → XP_024309796.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

      Conserved Domains (1) summary
      cd13733
      Location:190 → 365
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    2. XM_011531919.2 → XP_011530221.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

      Conserved Domains (1) summary
      cd13733
      Location:190 → 365
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    3. XM_006714207.4 → XP_006714270.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

      Conserved Domains (3) summary
      pfam10249
      Location:130 → 184
      NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cl02614
      Location:287 → 414
      SPRY; SPRY domain

    RNA

    1. XR_001741216.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      191484912..191498442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349927.1 → XP_054205902.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    2. XM_054349926.1 → XP_054205901.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    3. XM_054349925.1 → XP_054205900.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

    RNA

    1. XR_008486977.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9V2.1 GenPept UniProtKB/Swiss-Prot:Q8N9V2

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