epb41b erythrocyte membrane protein band 4.1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: epb41bprovided by ZNC
Official Full Name: erythrocyte membrane protein band 4.1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030130-1
See related: Ensembl:ENSDARG00000029019 AllianceGenome:ZFIN:ZDB-GENE-030130-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: P4.1R; epb41; wu:fb70c02
Summary: Enables calmodulin binding activity. Acts upstream of or within embryonic hemopoiesis and erythrocyte differentiation. Is extrinsic component of plasma membrane. Is expressed in blood; liver; ovary; and pericardial region. Human ortholog(s) of this gene implicated in hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (26449743..26488169)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (26576301..26614727)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that the gene product of ZF4.1R is essential for normal morphological shape of the developing heart and to support the repetitive cycles of its muscle contraction and relaxation.
Title: Two different unique cardiac isoforms of protein 4.1R in zebrafish, Danio rerio, and insights into their cardiac functions as related to their unique structures.
This study defines unique structural and functional properties for ZF4.1R.
Title: Characterization of protein 4.1R in erythrocytes of zebrafish (Danio rerio): unique binding properties with transmembrane proteins and calmodulin.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein 4.1b

Names: cha; chablis; erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked); erythrocyte membrane protein band 4.1b (elliptocytosis 1, RH-linked); merlot; mot; protein 4.1R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175084.3 → NP_778259.1 protein 4.1b

See identical proteins and their annotated locations for NP_778259.1

Status: VALIDATED

Source sequence(s)

BX571761, CR391910

UniProtKB/TrEMBL

B3DH29, F6NI73, Q8JG61

Related

ENSDARP00000039745.5, ENSDART00000039746.6

Conserved Domains (6) summary

smart00295
Location:4 → 193

B41; Band 4.1 homologues

cd13184
Location:188 → 281

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam00373
Location:88 → 193

FERM_M; FERM central domain

pfam04382
Location:1451 → 1497

SAB; SAB domain

pfam08736
Location:290 → 331

FA; FERM adjacent (FA)

pfam09379
Location:6 → 69

FERM_N; FERM N-terminal domain