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    Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316639, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Farp2provided by RGD
    Official Full Name
    FERM, ARH/RhoGEF and pleckstrin domain protein 2provided by RGD
    Primary source
    RGD:1308003
    See related
    Ensembl:ENSRNOG00000018051 AllianceGenome:RGD:1308003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; osteoclast differentiation; and podosome assembly. Predicted to act upstream of or within Rac protein signal transduction; hair cycle process; and neuron remodeling. Predicted to be located in cytoplasm. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 113.4), Kidney (RPKM 104.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q36
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101501061..101609092)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94053650..94161982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100660366..100767940)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC120094809 Neighboring gene septin 2 Neighboring gene 5S ribosomal RNA Neighboring gene serine/threonine kinase 25 Neighboring gene BCL2 family apoptosis regulator BOK

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. Takegahara N, et al. FASEB J, 2010 Dec. PMID 20702777
    2. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. He X, et al. Structure, 2013 Mar 5. PMID 23375260, Free PMC Article
    3. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. Kubo T, et al. J Neurosci, 2002 Oct 1. PMID 12351724, Free PMC Article
    4. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hair cycle process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    FERM, RhoGEF and pleckstrin domain protein 2
    FERM, RhoGEF and pleckstrin domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108233.2 → NP_001101703.1  FERM, ARHGEF and pleckstrin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001101703.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JR19, D3ZFK8
      Conserved Domains (6) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      cd00160
      Location:539 → 718
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:747 → 853
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:924 → 1021
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:333 → 375
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101501061..101609092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083771.2 → XP_038939699.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JR19, D3ZFK8
      Conserved Domains (6) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      cd00160
      Location:539 → 718
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:747 → 853
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:924 → 1021
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:333 → 375
      FA; FERM adjacent (FA)

    2. XM_039083770.2 → XP_038939698.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JR19, D3ZFK8
      Related
      ENSRNOP00000024440.5
      Conserved Domains (6) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      cd00160
      Location:539 → 718
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:747 → 853
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:924 → 1021
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:333 → 375
      FA; FERM adjacent (FA)

    3. XM_063267327.1 → XP_063123397.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JR19, D3ZFK8
    Nucleotide Protein Strain
    Heading Accession and Version

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