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    Pafah2 platelet-activating factor acetylhydrolase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pafah2provided by RGD
    Official Full Name
    platelet-activating factor acetylhydrolase 2provided by RGD
    Primary source
    RGD:631399
    See related
    Ensembl:ENSRNOG00000022288 AllianceGenome:RGD:631399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 175.0), Lung (RPKM 171.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151890751..151919896)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146607050..146636203)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152606850..152635956)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC120103006 Neighboring gene exostosin-like glycosyltransferase 1 Neighboring gene uncharacterized LOC102546373 Neighboring gene uncharacterized LOC134487004 Neighboring gene stathmin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. Karasawa K, et al. J Biol Chem, 1999 Mar 26. PMID 10085103
    2. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. Bonin F, et al. J Biol Chem, 2004 Dec 10. PMID 15456758
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables platelet-activating factor acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase 2, cytoplasmic
    Names
    PAF:lysophospholipid transacetylase
    PAF:sphingosine transacetylase
    SD-PLA2
    platelet-activating factor acetylhydrolase 2, 40kDa
    platelet-activating factor acetyltransferase PAFAH2
    serine-dependent phospholipase A2
    NP_808793.1
    XP_006239189.1
    XP_017448893.1
    XP_038965969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177932.2 → NP_808793.1  platelet-activating factor acetylhydrolase 2, cytoplasmic

      See identical proteins and their annotated locations for NP_808793.1

      Status: PROVISIONAL

      Source sequence(s)
      AY225592
      UniProtKB/Swiss-Prot
      P83006, Q80Z89
      UniProtKB/TrEMBL
      A6IT19, A6IT20
      Related
      ENSRNOP00000068571.1, ENSRNOT00000089070.2
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151890751..151919896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593404.3 → XP_017448893.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      P83006, Q80Z89
      UniProtKB/TrEMBL
      A6IT19, A6IT20
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    2. XM_039110041.2 → XP_038965969.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      P83006, Q80Z89
      UniProtKB/TrEMBL
      A6IT19, A6IT20
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    3. XM_006239127.5 → XP_006239189.1  platelet-activating factor acetylhydrolase 2, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006239189.1

      UniProtKB/Swiss-Prot
      P83006, Q80Z89
      UniProtKB/TrEMBL
      A6IT19, A6IT20
      Conserved Domains (1) summary
      pfam03403
      Location:1 → 379
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    RNA

    1. XR_001837842.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83006.2 GenPept UniProtKB/Swiss-Prot:P83006

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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