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    Dclk2 doublecortin-like kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310698, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dclk2provided by RGD
    Official Full Name
    doublecortin-like kinase 2provided by RGD
    Primary source
    RGD:1308384
    See related
    Ensembl:ENSRNOG00000016550 AllianceGenome:RGD:1308384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CL2; Dck2; CLICK2; CLICK-II; RGD1308384
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that this gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in Brain (RPKM 74.3), Adrenal (RPKM 64.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (174506660..174636353, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (172202733..172338411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (186116624..186245937, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene LPS responsive beige-like anchor protein Neighboring gene mab-21 like 2 Neighboring gene U1 spliceosomal RNA Neighboring gene CD1d1 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. Edelman AM, et al. J Biol Chem, 2005 Mar 4. PMID 15611072
    2. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Kerjan G, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19342486, Free PMC Article
    3. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Tuy FP, et al. Dev Neurosci, 2008. PMID 18075264
    4. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. Ohmae S, et al. J Biol Chem, 2006 Jul 21. PMID 16684769
    5. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Doublecortin kinase-2 is associated with terminal segments of axons and dendrites
      Title: Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hippocampus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyramidal neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyramidal neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DCLK2
    Names
    caMK-like CREB regulatory kinase 2
    doublecortin kinase 2
    doublecortin-like and CAM kinase-like 2
    NP_001009691.3
    NP_001182761.1
    XP_006232742.1
    XP_006232743.1
    XP_006232744.1
    XP_006232746.1
    XP_006232747.1
    XP_063137964.1
    XP_063137965.1
    XP_063137966.1
    XP_063137967.1
    XP_063137968.1
    XP_063137969.1
    XP_063137970.1
    XP_063137971.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009691.3 → NP_001009691.3  serine/threonine-protein kinase DCLK2 isoform b

      See identical proteins and their annotated locations for NP_001009691.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is an exon-5-containing transcript (PMIDs:15611072 and 18075264). It encodes the longer isoform (b).
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5MPA7, Q5MPA8, Q5MPA9, Q5MPB0
      UniProtKB/TrEMBL
      A0A8L2RA10
      Related
      ENSRNOP00000075203.2, ENSRNOT00000079954.2
      Conserved Domains (3) summary
      smart00220
      Location:409 → 666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:407 → 665
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    2. NM_001195832.1 → NP_001182761.1  serine/threonine-protein kinase DCLK2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 2. The resulting isoform (a) has a shorter and different C-terminus, as compared to isoform b.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8L2QVM1
      Related
      ENSRNOP00000062805.3, ENSRNOT00000066004.5
      Conserved Domains (3) summary
      smart00220
      Location:409 → 666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:407 → 665
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      174506660..174636353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281896.1 → XP_063137966.1  serine/threonine-protein kinase DCLK2 isoform X8

    2. XM_063281898.1 → XP_063137968.1  serine/threonine-protein kinase DCLK2 isoform X10

    3. XM_006232685.5 → XP_006232747.1  serine/threonine-protein kinase DCLK2 isoform X6

      UniProtKB/TrEMBL
      A0A8L2QQT4
      Related
      ENSRNOP00000022292.7
      Conserved Domains (3) summary
      smart00220
      Location:392 → 649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:390 → 648
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    4. XM_063281900.1 → XP_063137970.1  serine/threonine-protein kinase DCLK2 isoform X12

    5. XM_063281894.1 → XP_063137964.1  serine/threonine-protein kinase DCLK2 isoform X4

    6. XM_063281897.1 → XP_063137967.1  serine/threonine-protein kinase DCLK2 isoform X9

    7. XM_006232684.5 → XP_006232746.1  serine/threonine-protein kinase DCLK2 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QVM1
      Conserved Domains (3) summary
      smart00220
      Location:409 → 666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:407 → 665
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    8. XM_006232682.5 → XP_006232744.1  serine/threonine-protein kinase DCLK2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2RA10
      Conserved Domains (3) summary
      smart00220
      Location:392 → 649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:390 → 648
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    9. XM_006232681.5 → XP_006232743.1  serine/threonine-protein kinase DCLK2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2RA10
      Conserved Domains (3) summary
      smart00220
      Location:393 → 650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:391 → 649
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    10. XM_006232680.5 → XP_006232742.1  serine/threonine-protein kinase DCLK2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2RA10
      Conserved Domains (3) summary
      smart00220
      Location:408 → 665
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:406 → 664
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    11. XM_063281899.1 → XP_063137969.1  serine/threonine-protein kinase DCLK2 isoform X11

    12. XM_063281895.1 → XP_063137965.1  serine/threonine-protein kinase DCLK2 isoform X7

    13. XM_063281901.1 → XP_063137971.1  serine/threonine-protein kinase DCLK2 isoform X13

    RNA

    1. XR_351806.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MPA9.2 GenPept UniProtKB/Swiss-Prot:Q5MPA9

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