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    Rhog ras homolog family member G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308875, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rhogprovided by RGD
    Official Full Name
    ras homolog family member Gprovided by RGD
    Primary source
    RGD:621310
    See related
    Ensembl:ENSRNOG00000020393 AllianceGenome:RGD:621310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arhg
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; activation of GTPase activity; and cytoskeleton organization. Predicted to act upstream of or within several processes, including Rho protein signal transduction; positive regulation of transcription, DNA-templated; and regulation of ruffle assembly. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 120.2), Thymus (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166030685..166046254, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156618713..156630710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167336147..167347720, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ribosomal protein S29, pseudogene 1 Neighboring gene stromal interaction molecule 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental changes in expression of small GTPase RhoG mRNA in the rat brain. Ishikawa Y, et al. Brain Res Mol Brain Res, 2002 Oct 15. PMID 12393274
    2. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. Franke K, et al. EMBO J, 2012 Jun 29. PMID 22588079, Free PMC Article
    3. RhoG regulates gene expression and the actin cytoskeleton in lymphocytes. Vigorito E, et al. Oncogene, 2003 Jan 23. PMID 12545154
    4. RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. Ubba V, et al. Reprod Sci, 2017 May. PMID 27662902
    5. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. Kim JY, et al. J Biol Chem, 2011 Oct 28. PMID 21900250, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
      Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
    2. RHOG can mediate signaling through downstream effectors DOCK1 and RAC1 during ovarian follicular development (theca and granulosa cells and oocyte), but dehydroepiandrosterone downregulated them in the polycystic ovarian syndrome ovary.
      Title: RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
    3. Dock3 forms a complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling and induces neurite outgrowth via Rac1 activation in PC12 cells.
      Title: Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
    4. RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching.
      Title: miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
    5. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
      Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
    6. Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
      Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
    7. results suggest distinct pre- and postnatal roles in the development of the central nervous system
      Title: Developmental changes in expression of small GTPase RhoG mRNA in the rat brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125105

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoG
    Names
    ras homolog gene family, member G (rho G)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037195.1 → NP_001032272.1  rho-related GTP-binding protein RhoG

      See identical proteins and their annotated locations for NP_001032272.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107943
      UniProtKB/TrEMBL
      A0A8I6A3A8, Q32PX6
      Related
      ENSRNOP00000086185.1, ENSRNOT00000101823.1
      Conserved Domains (1) summary
      cd01875
      Location:1 → 191
      RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      166030685..166046254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229882.5 → XP_006229944.1  rho-related GTP-binding protein RhoG isoform X1

      See identical proteins and their annotated locations for XP_006229944.1

      UniProtKB/TrEMBL
      A0A8I6A3A8, Q32PX6
      Related
      ENSRNOP00000096983.1
      Conserved Domains (1) summary
      cd01875
      Location:1 → 191
      RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

    2. XM_006229883.5 → XP_006229945.1  rho-related GTP-binding protein RhoG isoform X1

      See identical proteins and their annotated locations for XP_006229945.1

      UniProtKB/TrEMBL
      A0A8I6A3A8, Q32PX6
      Related
      ENSRNOP00000027641.3
      Conserved Domains (1) summary
      cd01875
      Location:1 → 191
      RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

    3. XM_063262837.1 → XP_063118907.1  rho-related GTP-binding protein RhoG isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3A8, Q32PX6
    Nucleotide Protein Strain
    Heading Accession and Version

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