U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Proz protein Z, vitamin K-dependent plasma glycoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306608, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prozprovided by RGD
    Official Full Name
    protein Z, vitamin K-dependent plasma glycoproteinprovided by RGD
    Primary source
    RGD:1308666
    See related
    Ensembl:ENSRNOG00000019700 AllianceGenome:RGD:1308666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 974.3) and Kidney (RPKM 114.1) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16q12.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83150104..83165688, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76450013..76463558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81784348..81797889, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene PCI domain containing 2 Neighboring gene uncharacterized LOC134482531 Neighboring gene small ribosomal subunit protein eS19-like Neighboring gene coagulation factor X Neighboring gene coagulation factor VII

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Staton J, et al. Stroke, 2005 Jun. PMID 15879328
    2. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Lichy C, et al. Stroke, 2004 Jan. PMID 14671240
    3. Decreased protein Z concentrations complicating the hypercoagulable state of Behçet's disease. Oztürk MA, et al. Clin Appl Thromb Hemost, 2003 Jul. PMID 14507116
    4. Protein Z in ischemic stroke and its etiologic subtypes. McQuillan AM, et al. Stroke, 2003 Oct. PMID 12970515
    5. Protein Z influences the prothrombotic phenotype in Factor V Leiden patients. Kemkes-Matthes B, et al. Thromb Res, 2002 May 15. PMID 12297123

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    vitamin K-dependent protein Z

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309433.1 → NP_001296362.1  vitamin K-dependent protein Z precursor

      Status: VALIDATED

      Source sequence(s)
      BC160868, JAXUCZ010000016
      UniProtKB/TrEMBL
      B1H253, G3V8K8
      Related
      ENSRNOP00000026666.8, ENSRNOT00000026666.10
      Conserved Domains (5) summary
      smart00069
      Location:27 → 89
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:99 → 126
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00089
      Location:199 → 347
      Trypsin; Trypsin
      pfam14670
      Location:140 → 169
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl21584
      Location:199 → 404
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      83150104..83165688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600160.3 → XP_017455649.1  vitamin K-dependent protein Z isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2L4, B1H253
      Related
      ENSRNOP00000086614.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107325.1: Suppressed sequence

      Description
      NM_001107325.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous