Rpgrip1 RPGR interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpgrip1provided by RGD
Official Full Name: RPGR interacting protein 1provided by RGD
Primary source: RGD:1310807
See related: Ensembl:ENSRNOG00000011809 AllianceGenome:RGD:1310807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in detection of light stimulus involved in visual perception. Predicted to act upstream of or within eye development; neural precursor cell proliferation; and visual perception. Located in ciliary rootlet and ciliary transition zone. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 6; Leber hereditary optic neuropathy; cone-rod dystrophy 13; and retinitis pigmentosa. Orthologous to human RPGRIP1 (RPGR interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 198.2), Thymus (RPKM 31.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27282997..27341021)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24814576..24867522)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28521287..28575046)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138387 (e-PCR)
- UniSTS:220474

AA997586 (e-PCR)
- UniSTS:248418

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eye photoreceptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor distal connecting cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Names: retinitis pigmentosa GTPase regulator interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427786.1 → NP_001414715.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

27282997..27341021

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274229.1 → XP_063130299.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform X5
XM_063274225.1 → XP_063130295.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform X1
XM_063274228.1 → XP_063130298.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform X4
XM_063274226.1 → XP_063130296.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform X2
XM_063274227.1 → XP_063130297.1 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001030035.1: Suppressed sequence

Description

NM_001030035.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: RPGRIP1 (GeneID:282656).