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    Serpinb3 serpin family B member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304688, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Serpinb3provided by RGD
    Official Full Name
    serpin family B member 3provided by RGD
    Primary source
    RGD:1549766
    See related
    Ensembl:ENSRNOG00000070387 AllianceGenome:RGD:1549766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Predicted to be located in cytoplasmic vesicle; extracellular exosome; and nucleus. Predicted to be active in extracellular space. Orthologous to human SERPINB3 (serpin family B member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 20.7), Testes (RPKM 4.0) and 1 other tissue See more
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    Genomic context

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    Location:
    13p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (23788758..23795298, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (23274120..23280660, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (27186701..27193211, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene serpin family B member 13 Neighboring gene protein PRRC2B-like Neighboring gene serpin family B member 3A Neighboring gene serpin family B member 11 Neighboring gene uncharacterized LOC102553197 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SERPINB3 induces epithelial-mesenchymal transition. Quarta S, et al. J Pathol, 2010 Jul. PMID 20527027
    2. Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system. Moore PL, et al. J Biol Chem, 2003 Nov 21. PMID 12975381
    3. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Uemura Y, et al. Int J Cancer, 2000 Jul 20. PMID 10956412
    4. Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD. Turato C, et al. Exp Biol Med (Maywood), 2011 Mar. PMID 21383048
    5. Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. Masumoto K, et al. J Biol Chem, 2003 Nov 14. PMID 12949073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autocrine signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in paracrine signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serpin family B member 3
    Names
    serine protease inhibitor B3
    serpin peptidase inhibitor, clade B (ovalbumin), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395733.1 → NP_001382662.1  serpin family B member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1MAA9
      Conserved Domains (1) summary
      cl38926
      Location:1 → 387
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      23788758..23795298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249631.4 → XP_006249693.1  serpin family B member 3 isoform X1

      UniProtKB/TrEMBL
      F1MAA9
      Related
      ENSRNOP00000003475.3, ENSRNOT00000003475.5
      Conserved Domains (1) summary
      cl38926
      Location:1 → 387
      serpin; SERine Proteinase INhibitors (serpin) family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008887.1: Suppressed sequence

      Description
      NM_001008887.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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