Bop1 BOP1 ribosomal biogenesis factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bop1provided by RGD
Official Full Name: BOP1 ribosomal biogenesis factorprovided by RGD
Primary source: RGD:1310589
See related: Ensembl:ENSRNOG00000021773 AllianceGenome:RGD:1310589
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in several processes, including regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Predicted to act upstream of or within rRNA processing and ribosomal large subunit biogenesis. Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 120.9), Adrenal (RPKM 111.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (110052716..110076529, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108172062..108195875, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117514529..117538342, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI176339 (e-PCR)
- UniSTS:250195

AI169617 (e-PCR)
- UniSTS:250361

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PeBoW complex	ISO Inferred from Sequence Orthology more info
part_of PeBoW complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosome biogenesis protein BOP1

Names: block of proliferation 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024250.1 → NP_001019421.1 ribosome biogenesis protein BOP1

See identical proteins and their annotated locations for NP_001019421.1

Status: PROVISIONAL

Source sequence(s)

BC092594

UniProtKB/Swiss-Prot

Q562C2

UniProtKB/TrEMBL

A6HS98

Related

ENSRNOP00000025133.5, ENSRNOT00000025134.6

Conserved Domains (3) summary

smart01035
Location:129 → 387

BOP1NT; BOP1NT (NUC169) domain

cd00200
Location:393 → 731

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:402 → 440

7WD40; WD40 repeat [structural motif]