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    Prepl prolyl endopeptidase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298771, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Preplprovided by RGD
    Official Full Name
    prolyl endopeptidase-likeprovided by RGD
    Primary source
    RGD:1310143
    See related
    Ensembl:ENSRNOG00000007326 AllianceGenome:RGD:1310143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310143
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in Golgi to plasma membrane protein transport; regulation of synaptic vesicle exocytosis; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nucleus. Predicted to be active in Golgi apparatus and cytoskeleton. Predicted to colocalize with trans-Golgi network. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 550.3), Heart (RPKM 330.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prepl in Genome Data Viewer
    Location:
    6q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15333107..15362825)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9580367..9609957)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8316861..8346293, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479091 Neighboring gene solute carrier family 3 member 1 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1B Neighboring gene cilia- and flagella-associated protein 251-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PREPL deficiency: delineation of the phenotype and development of a functional blood assay. Régal L, et al. Genet Med, 2018 Jan. PMID 28726805
    2. PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome. Régal L, et al. Neurology, 2014 Apr 8. PMID 24610330, Free PMC Article
    3. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Lone AM, et al. J Am Chem Soc, 2011 Aug 3. PMID 21692504, Free PMC Article
    4. Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons. Morawski M, et al. Neuroscience, 2013 Jul 9. PMID 23485813
    5. Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A. Radhakrishnan K, et al. J Cell Sci, 2013 Mar 1. PMID 23321636

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC105586

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    prolyl endopeptidase-like
    NP_001010951.1
    XP_006239759.1
    XP_008762678.1
    XP_008762680.1
    XP_038967823.2
    XP_063117671.1
    XP_063117672.1
    XP_063117673.1
    XP_063117674.1
    XP_063117675.1
    XP_063117676.1
    XP_063117677.1
    XP_063117678.1
    XP_063117679.1
    XP_063117680.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010951.2 → NP_001010951.1  prolyl endopeptidase-like

      See identical proteins and their annotated locations for NP_001010951.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5HZA6
      UniProtKB/TrEMBL
      A6H9H3
      Conserved Domains (1) summary
      COG1770
      Location:26 → 574
      PtrB; Protease II [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15333107..15362825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261606.1 → XP_063117676.1  prolyl endopeptidase-like isoform X4

    2. XM_039111895.2 → XP_038967823.2  prolyl endopeptidase-like isoform X6

      UniProtKB/TrEMBL
      A0A8L2UN13

    3. XM_008764458.4 → XP_008762680.1  prolyl endopeptidase-like isoform X8

      See identical proteins and their annotated locations for XP_008762680.1

      UniProtKB/Swiss-Prot
      Q5HZA6
      UniProtKB/TrEMBL
      A6H9H3
      Conserved Domains (1) summary
      COG1770
      Location:26 → 574
      PtrB; Protease II [Amino acid transport and metabolism]

    4. XM_063261603.1 → XP_063117673.1  prolyl endopeptidase-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX67

    5. XM_063261610.1 → XP_063117680.1  prolyl endopeptidase-like isoform X8

      UniProtKB/TrEMBL
      A6H9H3

    6. XM_063261608.1 → XP_063117678.1  prolyl endopeptidase-like isoform X7

    7. XM_008764456.4 → XP_008762678.1  prolyl endopeptidase-like isoform X5

      UniProtKB/Swiss-Prot
      Q5HZA6
      Related
      ENSRNOP00000009660.7
      Conserved Domains (2) summary
      COG1770
      Location:91 → 639
      PtrB; Protease II [Amino acid transport and metabolism]
      cl21494
      Location:465 → 625
      Abhydrolase; alpha/beta hydrolases

    8. XM_063261601.1 → XP_063117671.1  prolyl endopeptidase-like isoform X1

    9. XM_063261602.1 → XP_063117672.1  prolyl endopeptidase-like isoform X1

    10. XM_006239697.5 → XP_006239759.1  prolyl endopeptidase-like isoform X2

      UniProtKB/Swiss-Prot
      Q5HZA6
      UniProtKB/TrEMBL
      A0A0G2JX67
      Related
      ENSRNOP00000076580.1
      Conserved Domains (2) summary
      COG1770
      Location:135 → 683
      PtrB; Protease II [Amino acid transport and metabolism]
      cl21494
      Location:509 → 669
      Abhydrolase; alpha/beta hydrolases

    11. XM_063261605.1 → XP_063117675.1  prolyl endopeptidase-like isoform X3

    12. XM_063261609.1 → XP_063117679.1  prolyl endopeptidase-like isoform X7

    13. XM_063261607.1 → XP_063117677.1  prolyl endopeptidase-like isoform X7

    14. XM_063261604.1 → XP_063117674.1  prolyl endopeptidase-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX67
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZA6.2 GenPept UniProtKB/Swiss-Prot:Q5HZA6

    Gene LinkOut

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