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    Trmo tRNA methyltransferase O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298072, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trmoprovided by RGD
    Official Full Name
    tRNA methyltransferase Oprovided by RGD
    Primary source
    RGD:1305420
    See related
    Ensembl:ENSRNOG00000009492 AllianceGenome:RGD:1305420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nap1; RGD1305420
    Summary
    Predicted to enable tRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Orthologous to human TRMO (tRNA methyltransferase O). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 49.8), Adrenal (RPKM 27.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65461489..65472019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60663106..60676423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (61992507..62001065, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sorbitol dehydrogenase, pseudogene 4 Neighboring gene forkhead box E1 Neighboring gene uncharacterized LOC120102868 Neighboring gene hemogen Neighboring gene prefoldin subunit 6, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. Kimura S, et al. Nucleic Acids Res, 2014 Aug. PMID 25063302, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116115

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (adenine(37)-N6)-methyltransferase
    Names
    nef-associated protein 1
    thioesterase NAP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025652.1 → NP_001020823.1  tRNA (adenine(37)-N6)-methyltransferase

      See identical proteins and their annotated locations for NP_001020823.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097981
      UniProtKB/Swiss-Prot
      Q4V7E0
      UniProtKB/TrEMBL
      A6IJB6, A6IJB7
      Related
      ENSRNOP00000012602.6, ENSRNOT00000012602.8
      Conserved Domains (2) summary
      pfam01980
      Location:45 → 164
      UPF0066; Uncharacterized protein family UPF0066
      pfam18389
      Location:325 → 387
      TrmO_C; TrmO C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      65461489..65472019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109455.2 → XP_038965383.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A6IJB6
      Conserved Domains (2) summary
      pfam01980
      Location:2 → 90
      UPF0066; Uncharacterized protein family UPF0066
      pfam18389
      Location:251 → 313
      TrmO_C; TrmO C-terminal domain

    2. XM_039109454.2 → XP_038965382.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A6IJB6
      Conserved Domains (2) summary
      pfam01980
      Location:56 → 175
      UPF0066; Uncharacterized protein family UPF0066
      pfam18389
      Location:336 → 398
      TrmO_C; TrmO C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7E0.1 GenPept UniProtKB/Swiss-Prot:Q4V7E0

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