Sv2c synaptic vesicle glycoprotein 2c [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sv2cprovided by RGD
Official Full Name: synaptic vesicle glycoprotein 2cprovided by RGD
Primary source: RGD:619718
See related: Ensembl:ENSRNOG00000018094 AllianceGenome:RGD:619718
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission; neurotransmitter transport; and transmembrane transport. Located in synaptic vesicle. Is integral component of synaptic vesicle membrane. Orthologous to human SV2C (synaptic vesicle glycoprotein 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 91.5), Adrenal (RPKM 19.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (28967631..29163168, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (27232933..27428479, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (26495757..26707691, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
Title: SV2 is the protein receptor for botulinum neurotoxin A.
SV2-synaptotagmin interaction act in regulated exocytosis and SV2A and SV2C, via their additional synaptotagmin binding site, function differently than SV2B.
Title: SV2A and SV2C contain a unique synaptotagmin-binding site.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139477 (e-PCR)
- UniSTS:221563

BE108455 (e-PCR)
- UniSTS:247766

AI179314 (e-PCR)
- UniSTS:261098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptic vesicle glycoprotein 2C

Names: synaptic vesicle protein 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031593.2 → NP_113781.1 synaptic vesicle glycoprotein 2C

See identical proteins and their annotated locations for NP_113781.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9Z2I6

UniProtKB/TrEMBL

A6I4Z9

Related

ENSRNOP00000024459.3, ENSRNOT00000024459.7

Conserved Domains (3) summary

cd06174
Location:155 → 719

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR01299
Location:1 → 727

synapt_SV2; synaptic vesicle protein SV2

pfam13576
Location:507 → 561

Pentapeptide_3; Pentapeptide repeats (9 copies)