Psme1 proteasome activator subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psme1provided by RGD
Official Full Name: proteasome activator subunit 1provided by RGD
Primary source: RGD:3429
See related: Ensembl:ENSRNOG00000019041 AllianceGenome:RGD:3429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable endopeptidase activator activity. Predicted to be involved in positive regulation of endopeptidase activity; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1850.7), Spleen (RPKM 1041.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33038962..33041849)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29069012..29071888)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34256071..34258947)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain.
Title: Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain.
PA28alphaOE is sufficient to up-regulate 11S proteasomes, enhance proteasome-mediated removal of misfolded and oxidized proteins, and protect against oxidative stress in cardiomyocytes
Title: Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237187 (e-PCR)
- UniSTS:237187

Psme1 (e-PCR), detects polymorphism
- UniSTS:144281

AW413925 (e-PCR)
- UniSTS:180660

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to endopeptidase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome activator complex subunit 1

Names: 11S regulator complex subunit alpha; PA28a; PA28alpha; REG-alpha; activator of multicatalytic protease subunit 1; protease (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) activator subunit 1; proteasome activator 28 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017264.3 → NP_058960.2 proteasome activator complex subunit 1

See identical proteins and their annotated locations for NP_058960.2

Status: PROVISIONAL

Source sequence(s)

BC060574

UniProtKB/Swiss-Prot

Q63797

UniProtKB/TrEMBL

F7F0J8, Q6P9V7

Related

ENSRNOP00000025887.3, ENSRNOT00000025887.6

Conserved Domains (2) summary

pfam02251
Location:8 → 68

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:104 → 246

PA28_beta; Proteasome activator pa28 beta subunit